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[电离辐射和免疫调节剂对移植物抗宿主反应发展的影响]

[The effect of ionizing radiation and immunomodulators on the development of the graft versus host reaction].

作者信息

Vasin M V, Chernov Iu N, Semenova L A, L'vova T S

出版信息

Radiobiologiia. 1991 May-Jun;31(3):368-71.

PMID:1887003
Abstract

The reaction "transplant against host" (RTAH) was performed by subcutaneous transplantation of popliteal lymphnode lymphocytes of C57Bl/6 mice (CBA X C57Bl/6)F1 mice. gamma-Irradiation of donors with a dose of 6 Gy was shown to activate the function of T-lymphocytes, effectors in RTAH. Recipients irradiated with the same dose exhibited a drastic decrease in the ability of the organism to restrict RTAH. Decaris administered 15 min after irradiation of donors removed the postirradiation RTAH increase. In nonirradiated donors or recipients, the immunomodulators increased RTAH.

摘要

通过皮下移植C57Bl/6小鼠(CBA×C57Bl/6)F1小鼠的腘窝淋巴结淋巴细胞来进行“移植物抗宿主”反应(RTAH)。结果显示,用6 Gy剂量对供体进行γ射线照射可激活RTAH中效应物T淋巴细胞的功能。用相同剂量照射的受体表现出机体限制RTAH能力的急剧下降。在供体照射后15分钟给予地卡瑞司可消除照射后RTAH的增加。在未照射的供体或受体中,免疫调节剂可增加RTAH。

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Radiobiologiia. 1991 May-Jun;31(3):368-71.
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