Sula K, Nouza K
Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague.
Exp Clin Immunogenet. 1984;1(3):175-84.
Genetic resistance (GR) of (B10 x A/Ph)F1 hybrid mice to parental B10 grafts limits the 'performance' of both hemopoietic and lymphoid cells. In comparison with A/Ph spleen cells, B10 cells induce only a slight regional graft-versus-host (GVH) reaction and a delayed systemic GVH reaction. The GR to lymphoid cells is not sensitive to total body irradiation, to cyclophosphamide, or to various xenogeneic sera (e.g. antilymphocyte, antimacrophage, antithymocyte). A high dose of antimarrow serum was partially effective, but the most suppressive effect was obtained by treatment with silica. Besides some similar features, GR action on hemopoietic and lymphoid cells revealed several differences and the nature of these is discussed.
（B10×A/Ph）F1 杂交小鼠对亲代 B10 移植物的遗传抗性（GR）限制了造血细胞和淋巴细胞的“性能”。与 A/Ph 脾细胞相比，B10 细胞仅诱导轻微的局部移植物抗宿主（GVH）反应和延迟的全身 GVH 反应。对淋巴细胞的 GR 对全身照射、环磷酰胺或各种异种血清（如抗淋巴细胞、抗巨噬细胞、抗胸腺细胞血清）不敏感。高剂量的抗骨髓血清有部分效果，但用二氧化硅处理获得的抑制效果最强。除了一些相似特征外，GR 对造血细胞和淋巴细胞的作用还显示出一些差异，并对这些差异的性质进行了讨论。
