Odeleye O E, Watson R R
Department of Nutritional Sciences, University of Arizona, Tucson 85724.
Prog Food Nutr Sci. 1991;15(1-2):1-19.
The literature is briefly summarized as to immunologic modifications caused by the human acquired immune deficiency syndrome (AIDS), immunocompetence at various nutritional states of vitamin E, and the immunoenhancing properties of vitamin E. The abnormalities of immune components present in AIDS are similar to those that are stimulated or restored by intake of high doses of vitamin E. Dietary supplementation of vitamin E with an adequate nutrition support or concomitant use of this vitamin with current drug therapies [For example, Zidovudine (AZT)] may increase the therapeutic efficiency of drugs and enhance immune resistance to opportunistic infections associated with AIDS. Supplementation with vitamin E may also decrease the progression of the disease to AIDS. Unlike many pharmacological agents which are toxic at low levels, vitamin E is non-toxic over a wide range of intakes. A moderately high dose may be used to target and stimulate some specific immune cells destroyed by HIV infection. However, further interdisciplinary studies are much needed to relate various levels of intake of this vitamin as a supplement to clinical outcomes during HIV infection and establish the role for this vitamin in human immunity during AIDS.
本文简要综述了人类获得性免疫缺陷综合征（AIDS）引起的免疫改变、维生素E在不同营养状态下的免疫能力以及维生素E的免疫增强特性。AIDS患者存在的免疫成分异常与高剂量维生素E摄入所刺激或恢复的异常相似。在充足营养支持下进行维生素E膳食补充，或该维生素与当前药物疗法（如齐多夫定，AZT）同时使用，可能会提高药物的治疗效果，并增强对AIDS相关机会性感染的免疫抵抗力。补充维生素E还可能减缓疾病向AIDS的进展。与许多低剂量即有毒性的药物不同，维生素E在广泛的摄入量范围内都是无毒的。中等高剂量可用于靶向和刺激一些被HIV感染破坏的特定免疫细胞。然而，迫切需要进一步开展跨学科研究，以关联该维生素不同摄入水平与HIV感染期间的临床结局，并确定该维生素在AIDS患者免疫中的作用。
