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1
Immunochemical studies on blood groups; chemical changes associated with destruction of blood group activity and enhancement of the type XIV cross-reactivity by partial hydrolysis of hog and human blood group A, B, and O substances.血型的免疫化学研究；猪和人血型A、B及O物质经部分水解后与血型活性破坏及十四型交叉反应性增强相关的化学变化。
J Exp Med. 1948 Jul;88(1):43-57. doi: 10.1084/jem.88.1.43.
2
Immunochemical studies on blood groups; the methylpentose contents of hog and human blood group A and O substances and their relationship to cross-reactivity with type XIV antipneumococcus horse serum.血型的免疫化学研究；猪和人 A 型及 O 型血型物质的甲基戊糖含量及其与 XIV 型抗肺炎球菌马血清交叉反应性的关系。
J Exp Med. 1948 Jul;88(1):59-63. doi: 10.1084/jem.88.1.59.
3
Immunochemical studies on blood groups; the cross reaction between type XIV antipneumococcal horse serum and purified blood group A, B, and O substances from hog and human sources.血型的免疫化学研究；十四型抗肺炎球菌马血清与从猪和人源纯化的A、B和O血型物质之间的交叉反应。
J Exp Med. 1948 Apr 1;87(4):295-300. doi: 10.1084/jem.87.4.295.
4
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : IV. PREPARATION OF BLOOD GROUP A SUBSTANCES FROM HUMAN SOURCES AND A COMPARISON OF THEIR CHEMICAL AND IMMUNOCHEMICAL PROPERTIES WITH THOSE OF THE BLOOD GROUP A SUBSTANCE FROM HOG STOMACH.免疫化学血液研究：IV. 从人源制备血型 A 物质，并与猪胃来源的血型 A 物质的化学和免疫化学性质进行比较。
J Exp Med. 1947 May 31;85(6):685-99. doi: 10.1084/jem.85.6.685.
5
Immuno-chemical studies on blood groups; the preparation of blood group A and B substances and an inactive substance from individual horse stomachs and of blood group B substance from human saliva.血型的免疫化学研究；从个体马胃中制备血型A和B物质以及一种无活性物质，以及从人唾液中制备血型B物质。
J Exp Med. 1950 Jan 1;91(1):105-14. doi: 10.1084/jem.91.1.105.
6
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : XI. SPECIES DIFFERENCES AMONG BLOOD GROUP A SUBSTANCES.免疫化学血液研究：十一。A 血型物质的种属差异。
J Exp Med. 1950 Mar 31;91(4):433-45. doi: 10.1084/jem.91.4.433.
7
Immunochemical studies on blood groups; specific precipitation of the fucose of hog and human blood group A substances by anti-A.血型的免疫化学研究；抗A对猪和人类血型A物质中岩藻糖的特异性沉淀反应。
J Exp Med. 1949 Jan;89(1):1-10. doi: 10.1084/jem.89.1.1.
8
Immunochemical studies on blood groups. XXIII. Studies on the cross reactivity of untreated and partially hydrolyzed blood group A, B and O(H) substances with type XIV antipneumococcal horse sera.血型的免疫化学研究。二十三。未处理及部分水解的A、B、O(H)血型物质与十四型抗肺炎球菌马血清交叉反应性的研究。
J Immunol. 1959 Apr;82(4):358-72.
9
Immunochemical studies on blood groups. XLVI. Oligosaccharides isolated after hydrolysis of hog gastric mucin blood group A + H substance previously treated with the blood group de-N-acetylating enzyme.血型的免疫化学研究。XLVI. 猪胃粘蛋白血型A + H物质经血型去N-乙酰化酶处理后水解得到的寡糖。
Arch Biochem Biophys. 1970 Dec;141(2):588-601. doi: 10.1016/0003-9861(70)90178-5.
10
THE IMMUNOLOGICAL RELATIONSHIP OF THE CAPSULAR POLYSACCHARIDE OF TYPE XIV PNEUMOCOCCUS TO THE BLOOD GROUP A SPECIFIC SUBSTANCE.第十四型肺炎球菌荚膜多糖与 A 血型特异性物质的免疫学关系。
J Exp Med. 1939 Aug 31;70(3):239-47. doi: 10.1084/jem.70.3.239.

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Glycan binding profile of a fucolectin-related protein (FRP) encoded by the SP2159 gene of .由……的SP2159基因编码的一种岩藻糖结合凝集素相关蛋白（FRP）的聚糖结合谱
Biochim Open. 2017 Dec 23;6:17-23. doi: 10.1016/j.biopen.2017.12.002. eCollection 2018 Jun.
2
Immunochemical studies on blood groups; the methylpentose contents of hog and human blood group A and O substances and their relationship to cross-reactivity with type XIV antipneumococcus horse serum.血型的免疫化学研究；猪和人 A 型及 O 型血型物质的甲基戊糖含量及其与 XIV 型抗肺炎球菌马血清交叉反应性的关系。
J Exp Med. 1948 Jul;88(1):59-63. doi: 10.1084/jem.88.1.59.
3
Immunochemical studies on blood groups; specific precipitation of the fucose of hog and human blood group A substances by anti-A.血型的免疫化学研究；抗A对猪和人类血型A物质中岩藻糖的特异性沉淀反应。
J Exp Med. 1949 Jan;89(1):1-10. doi: 10.1084/jem.89.1.1.
4
Differential affinities of Erythrina cristagalli lectin (ECL) toward monosaccharides and polyvalent mammalian structural units.刺桐凝集素（ECL）对单糖和多价哺乳动物结构单元的不同亲和力。
Glycoconj J. 2007 Dec;24(9):591-604. doi: 10.1007/s10719-007-9063-y. Epub 2007 Sep 6.
5
Immuno-chemical studies on blood groups; the preparation of blood group A and B substances and an inactive substance from individual horse stomachs and of blood group B substance from human saliva.血型的免疫化学研究；从个体马胃中制备血型A和B物质以及一种无活性物质，以及从人唾液中制备血型B物质。
J Exp Med. 1950 Jan 1;91(1):105-14. doi: 10.1084/jem.91.1.105.
6
Differential binding characteristics and applications of DGal beta 1----3DGalNAc specific lectins.β1-3 特异性连接的 N-乙酰半乳糖胺半乳糖凝集素的差异结合特性及应用
Mol Cell Biochem. 1984;61(2):131-41. doi: 10.1007/BF00222491.
7
Immunochemical studies on blood groups. XLVII. The I antigen complex--precursors in the A, B, H, Lea, and leb blood group system--hemagglutination-inhibition studies.血型的免疫化学研究。XLVII. I抗原复合物——A、B、H、Lea和Leb血型系统中的前体——血凝抑制研究。
J Exp Med. 1971 Jan 1;133(1):39-52. doi: 10.1084/jem.133.1.39.

本文引用的文献

1
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : IV. PREPARATION OF BLOOD GROUP A SUBSTANCES FROM HUMAN SOURCES AND A COMPARISON OF THEIR CHEMICAL AND IMMUNOCHEMICAL PROPERTIES WITH THOSE OF THE BLOOD GROUP A SUBSTANCE FROM HOG STOMACH.免疫化学血液研究：IV. 从人源制备血型 A 物质，并与猪胃来源的血型 A 物质的化学和免疫化学性质进行比较。
J Exp Med. 1947 May 31;85(6):685-99. doi: 10.1084/jem.85.6.685.
2
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : III. PROPERTIES OF PURIFIED BLOOD GROUP A SUBSTANCES FROM INDIVIDUAL HOG STOMACH LININGS.免疫化学血液研究：III. 从个体猪胃衬里中纯化的 A 型血液物质的特性。
J Exp Med. 1946 May 31;83(6):485-97.
3
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : II. PROPERTIES OF THE BLOOD GROUP A SUBSTANCE FROM POOLS OF HOO STOMACHS AND OF SPECIFIC PRECIPITATES COMPOSED OF "A" SUBSTANCE AND HOMOLOGOUS HUMAN ANTIBODY.免疫化学血液研究：二、从幽门胃溶液和由“A”物质与同源人抗体组成的特定沉淀物中提取的 A 物质的特性。
J Exp Med. 1946 May 31;83(6):477-84.
4
A FURTHER STUDY OF THE CROSS REACTION BETWEEN THE SPECIFIC POLYSACCHARIDES OF TYPES III AND VIII PNEUMOCOCCI IN HORSE ANTISERA.马抗血清中Ⅲ型和Ⅷ型肺炎球菌特异性多糖的交叉反应的进一步研究。
J Exp Med. 1942 Jan 1;75(1):35-47. doi: 10.1084/jem.75.1.35.
5
A QUANTITATIVE STUDY OF THE CROSS REACTION OF TYPES III AND VIII PNEUMOCOCCI IN HORSE AND RABBIT ANTISERA.马和兔抗血清中Ⅲ型和Ⅷ型肺炎球菌的定量交叉反应研究。
J Exp Med. 1937 Mar 31;65(4):487-96. doi: 10.1084/jem.65.4.487.
6
Immunochemical studies on blood groups; the cross reaction between type XIV antipneumococcal horse serum and purified blood group A, B, and O substances from hog and human sources.血型的免疫化学研究；十四型抗肺炎球菌马血清与从猪和人源纯化的A、B和O血型物质之间的交叉反应。
J Exp Med. 1948 Apr 1;87(4):295-300. doi: 10.1084/jem.87.4.295.
7
Immunochemical studies on blood groups; the methylpentose contents of hog and human blood group A and O substances and their relationship to cross-reactivity with type XIV antipneumococcus horse serum.血型的免疫化学研究；猪和人 A 型及 O 型血型物质的甲基戊糖含量及其与 XIV 型抗肺炎球菌马血清交叉反应性的关系。
J Exp Med. 1948 Jul;88(1):59-63. doi: 10.1084/jem.88.1.59.
8
The amino-aciduria in Fanconi syndrome. A study making extensive use of techniques based on paper partition chromatography.范科尼综合征中的氨基酸尿症。一项大量运用基于纸分配色谱法技术的研究。
Biochem J. 1947;41(2):240-53. doi: 10.1042/bj0410240.
9
Chemistry of tissues: 2. Polysaccharides showing blood group A-specificity and the nature of the constituent units of the stable carbohydrate residue of the A substance from pepsin.组织化学：2. 显示血型A特异性的多糖以及胃蛋白酶作用下A物质稳定碳水化合物残基组成单位的性质
Biochem J. 1946;40(1):124-30. doi: 10.1042/bj0400124.
10
Qualitative analysis of proteins: a partition chromatographic method using paper.蛋白质的定性分析：一种使用滤纸的分配色谱法。
Biochem J. 1944;38(3):224-32. doi: 10.1042/bj0380224.

血型的免疫化学研究；猪和人血型A、B及O物质经部分水解后与血型活性破坏及十四型交叉反应性增强相关的化学变化。

Immunochemical studies on blood groups; chemical changes associated with destruction of blood group activity and enhancement of the type XIV cross-reactivity by partial hydrolysis of hog and human blood group A, B, and O substances.

作者信息

KABAT E A, BAER H

出版信息

J Exp Med. 1948 Jul;88(1):43-57. doi: 10.1084/jem.88.1.43.

DOI:10.1084/jem.88.1.43
PMID:18871876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2135803/
Abstract
  1. The effect of heating at varying pH on the cross-reactivity of hog blood group A and 0 substances with Type XIV antibody has been investigated. The hydrolysis of blood group A, B, and O substances from hog and human sources at pH 1.5-1.8 resulted in destruction of blood group activity and a marked increase in cross-reactivity with Type XIV antipneumococcus horse serum. 2. Analysis revealed the liberation of reducing sugar, most of which was dialyzable. It was further shown that the major part of the reducing sugar was fucose with small amounts of free and polymerized galactose and glucosamine. Non-glucosamine nitrogen, probably amino acids, also was found in the dialysate. 3. Paper chromatographic separation of the concentrated dialysate confirmed the presence of fucose and showed that the majority of the galactose and glucosamine occurred in polymeric form. 4. Quantitative analysis of the substances isolated from the paper showed good recovery of the various components, indicating that practically all of the material in the dialysate could be accounted for. 5. The methylpentose of human blood group A substance was identified as fucose. 6. The structure of the blood group substances is interpreted in terms of these results.
摘要
  1. 研究了在不同pH值下加热对猪A血型和O血型物质与XIV型抗体交叉反应性的影响。在pH 1.5 - 1.8条件下，猪源和人源的A、B、O血型物质发生水解，导致血型活性破坏，并与XIV型抗肺炎球菌马血清的交叉反应性显著增加。2. 分析表明有还原糖释放，其中大部分是可透析的。进一步表明，还原糖的主要成分是岩藻糖，还有少量游离和聚合的半乳糖及葡糖胺。透析液中还发现了非葡糖胺氮，可能是氨基酸。3. 对浓缩透析液进行纸色谱分离，证实了岩藻糖的存在，并表明大部分半乳糖和葡糖胺以聚合形式存在。4. 对从纸上分离出的物质进行定量分析，结果显示各种成分的回收率良好，这表明透析液中的几乎所有物质都能得到解释。5. 人A血型物质的甲基戊糖被鉴定为岩藻糖。6. 根据这些结果对血型物质的结构进行了解释。