Shaheen A A, Hassan S M
Biochemistry Department, Faculty of Pharmacy, Cairo University, Egypt.
Strahlenther Onkol. 1991 Aug;167(8):498-501.
Radioprotective effect of cysteine, vitamin E and their combination on gamma-irradiation-induced alteration in some haematological parameters in male rats has been studied 24 and 48 hrs after whole-body gamma-irradiation at a dose level of 7.5 Gy. The results of this study reveal that gamma-irradiation caused a significant decrease in red blood cells (RBCs) count with insignificant change in hemoglobin level, 24 and 48 hrs postirradiation, gamma-irradiated rats showed as well a progressive decrease in their blood ATP, and serum-SH levels with a significant increase in blood glutathione (GSH) level. Administration of cysteine or vitamin E preceding gamma-radiation exposure gave a significant radioprotection to the above haematological parameters. However, combination of both agents afforded a better protection, so that most of the measured parameters were restored to the pre-irradiated values. Finally, the date demonstrate that the radioprotection provided by combined administration of vitamin E and cysteine is feasible and perhaps, even more efficient against radiation injury to RBCs. This will appreciate the usage of such combination in protecting the patient during radiotherapy.
在全身γ射线以7.5 Gy剂量照射后24小时和48小时，研究了半胱氨酸、维生素E及其组合对γ射线照射诱导的雄性大鼠某些血液学参数改变的辐射防护作用。本研究结果表明，γ射线照射导致红细胞（RBC）计数显著降低，而血红蛋白水平无显著变化，照射后24小时和48小时，受γ射线照射的大鼠血液ATP和血清-SH水平也逐渐降低，血液谷胱甘肽（GSH）水平显著升高。在γ射线照射前给予半胱氨酸或维生素E对上述血液学参数有显著的辐射防护作用。然而，两种药物联合使用提供了更好的保护，因此大多数测量参数恢复到照射前的值。最后，数据表明维生素E和半胱氨酸联合给药提供的辐射防护是可行的，甚至可能对红细胞辐射损伤更有效。这将有利于在放射治疗期间使用这种组合来保护患者。
