Artamonov V A, Akhmadi S, Polianskaia I S
Ter Arkh. 1991;63(5):22-4.
Altogether 52 children suffering from reactive arthritis were placed under observation. In 45 patients arthritis developed after nasopharyngeal infection and was marked by a favourable course with a rapid positive dynamics. 7 children with a history of intestinal infection manifested Reiter's syndrome; in these children arthritis was characterized by a grave and prolonged course and by a high laboratory activity. HLA A10 (RR = 2.7), B27 (RR = 2.5) and DR2 (RR = 2.19) antigen were detected significantly more frequently in ReA patients who suffered nasopharyngeal infection. In children with Reiter's syndrome, the genetic markers of predisposition to the disease were HLA A10 (RR = 5.93) and B27 (RR = 149.1) antigens.
共有52名反应性关节炎患儿接受观察。45例患者在鼻咽部感染后出现关节炎，病程良好，有快速的积极变化。7例有肠道感染史的儿童表现为赖特综合征；这些儿童的关节炎特点是病程严重且迁延，实验室指标活跃。在因鼻咽部感染而患反应性关节炎的患者中，HLA A10（相对危险度=2.7）、B27（相对危险度=2.5）和DR2（相对危险度=2.19）抗原的检测频率明显更高。在患赖特综合征的儿童中，该疾病易感性的遗传标记是HLA A10（相对危险度=5.93）和B27（相对危险度=149.1）抗原。
