Kousa M, Lassus A, Karvonen J, Tillikainen A, Aho K
J Rheumatol. 1977 Spring;4(1):95-102.
Starting from index patients with confirmed Reiter's disease, a clinical and immunogenetic study was performed on 12 families in which there were further cases of arthritis. Altogether 51 family members were investigated and some information was available on 15 additional members. In most families there were two or three affected members in addition to the proband. The manifestations included acute polyarthritis (16 cases), which frequently followed urethritis or occurred as a complication of Yersinia or Shigella infection, and chronic arthritis (9 cases), either ankylosing spondylitis or peripheral arthritis. The latter characteristically had a remitting course, affecting mainly the large joints. Not a single subject had sero-positive rheumatoid arthritis. The HLA B27 gene was detected in all 12 families, and served as the main indicator of the familial trait for developing arthritis. In individual patients however, the association was not especially close, since there were members with this antigen who did not have arthritis in spite of a seemingly adequate triggering stimulus and others who had arthritis but not the antigen.
从确诊为赖特综合征的索引患者开始，对12个有其他关节炎病例的家庭进行了临床和免疫遗传学研究。共调查了51名家庭成员，另外15名成员也提供了一些信息。在大多数家庭中，除先证者外还有两三名患病成员。临床表现包括急性多关节炎（16例），常继发于尿道炎或作为耶尔森菌或志贺菌感染的并发症出现，以及慢性关节炎（9例），即强直性脊柱炎或外周关节炎。后者的特点是病程呈缓解性，主要影响大关节。无一例患者为血清阳性类风湿关节炎。在所有12个家庭中均检测到HLA B27基因，该基因是发生关节炎家族特征的主要指标。然而，在个体患者中，这种关联并不特别紧密，因为有些携带该抗原的成员尽管有看似充分的触发刺激却未患关节炎，而另一些患有关节炎的成员却没有该抗原。
