Guscetti F, Pospischil A, Läuchli C, Ehrensperger F
Institut für Veterinärpathologie, Universität Zürich.
Tierarztl Prax. 1991 Jun;19(3):296-301.
The histopathologic, immunohistochemical and electronmicroscopic findings of four dysautonomic cats are presented. The main histopathologic changes were seen in the nervous system, e.g. in sympathetic and parasympathetic ganglia that were similarly affected. Acute cases showed a degeneration of most of the neurons, in one subacute case less neurons and degeneration of some of the remaining neurons were present. Degenerating neurons were swollen or shrunken and had pycnotic, eccentric nuclei. The Nissl substance was lost, the cytoplasma stained eosinophilic and was often vacuolated. Degenerating neurons were also seen in some nuclei of cranial nerves. In sympathetic ganglia numbers of glial cells were increased as shown by immunohistochemical markers (GFAP, S-100). The main ultrastructural changes in sympathetic ganglia were eccentric, crenated nuclei, loss of Nissl substance, loss of ribosomes, distended cisternae and vacuoles filled with floccular material. Circular stacks of parallel smooth-membranes and autophagic vacuoles were also often seen. No normal Golgi fields were seen. These findings closely resemble those already described for feline dysautonomia.
本文呈现了四只自主神经功能异常猫的组织病理学、免疫组织化学和电子显微镜检查结果。主要组织病理学变化见于神经系统，如交感神经节和副交感神经节均受到类似影响。急性病例显示大多数神经元发生变性，在一例亚急性病例中，神经元数量减少，部分剩余神经元发生变性。变性神经元肿胀或萎缩，核固缩、偏心。尼氏体消失，细胞质嗜酸性染色，常出现空泡。在一些脑神经核中也可见到变性神经元。免疫组织化学标记物（GFAP、S-100）显示交感神经节中胶质细胞数量增加。交感神经节的主要超微结构变化为偏心、有锯齿的核，尼氏体消失，核糖体丢失，内质网池扩张，充满絮状物质的空泡。还常可见到平行光滑膜的圆形堆叠和自噬空泡。未见正常的高尔基体区域。这些发现与已报道的猫自主神经功能异常极为相似。
