Srividya A, Pani S P, Rajagopalan P K, Bundy D A, Grenfell B T
Vector Control Research Centre, Medical Complex, Indira Nagar, Pondicherry, India.
Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):255-9. doi: 10.1016/0035-9203(91)90046-2.
This study examines the relationship between the dynamic of Wuchereria bancrofti infection and the development of chronic lymphatic disease. Data sets from Pondicherry, south India, and Calcutta are used to estimate the age-specific proportion of the endemic population which has converted from microfilaria positive to amicrofilaraemia, and is assumed to be at risk of disease. For men, but not women, the age-prevalence profile of the estimated population 'at risk' is shown to correspond closely to the observed age-prevalence of chronic lymphatic disease in the same community. For both sexes, and independent of age, approximately 11% of the population at risk eventually develop lymphoedema. These observations suggest that filariasis endemic populations consist of those individuals who remain amicrofilaraemic and asymptomatic, and those who progress through the sequence: uninfected, microfilaraemic, amicrofilaraemic, to develop irreversible obstructive lymphatic pathology.
本研究探讨了班氏吴策线虫感染动态与慢性淋巴疾病发展之间的关系。来自印度南部本地治里和加尔各答的数据集用于估算流行地区特定年龄组中已从微丝蚴阳性转变为无微丝蚴血症的人群比例，这些人群被认为有患病风险。对于男性而非女性，估计的“有风险”人群的年龄患病率分布与同一社区中观察到的慢性淋巴疾病的年龄患病率密切相关。对于男女两性，且与年龄无关，约11%的有风险人群最终会发展为淋巴水肿。这些观察结果表明，丝虫病流行地区的人群包括那些保持无微丝蚴血症且无症状的个体，以及那些经历以下过程的个体：未感染、微丝蚴血症、无微丝蚴血症，进而发展为不可逆的阻塞性淋巴病理状态。
