Wangoo D, Thind S K, Gupta G S, Nath R
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Urol Res. 1991;19(3):203-6. doi: 10.1007/BF00303752.
Urinary citrate excretion was estimated colorimetrically from urine samples collected every 3 h for 24 h from 25 healthy adult males (non-stone formers; mean age 39 +/- 7 years) and 25 male patients suffering from calcium nephrolithiasis (stone formers; mean age 41 +/- 6 years). The 24 h citrate excretion was 2.47 +/- 0.65 mmol in non-stone formers and 2.02 +/- 0.71 mmol in stone formers. This difference was not significant. However, cosinor rhythmometry revealed a significant circadian rhythmicity in urinary citrate excretion in the healthy males which was absent in the stone formers; the amplitude was 0.06 mmol in non-stone formers and 0.017 mmol in stone formers. The acrophase was located at 14:25 h in non-stone formers and at 23:30 h in stone formers.
通过比色法对25名健康成年男性（非结石形成者；平均年龄39±7岁）和25名患有钙肾结石的男性患者（结石形成者；平均年龄41±6岁）每3小时收集一次的24小时尿液样本中的尿枸橼酸盐排泄量进行估算。非结石形成者24小时枸橼酸盐排泄量为2.47±0.65毫摩尔，结石形成者为2.02±0.71毫摩尔。这种差异不显著。然而，余弦节律分析显示，健康男性的尿枸橼酸盐排泄存在显著的昼夜节律，而结石形成者则不存在；非结石形成者的振幅为0.06毫摩尔，结石形成者为0.017毫摩尔。非结石形成者的峰值相位位于14:25时，结石形成者位于23:30时。
