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兔出血症病毒的基因组RNA和亚基因组RNA均与蛋白质相连并包装进病毒粒子中。

Genomic and subgenomic RNAs of rabbit hemorrhagic disease virus are both protein-linked and packaged into particles.

作者信息

Meyers G, Wirblich C, Thiel H J

机构信息

Federal Research Centre for Virus Diseases of Animals, Tübingen, Federal Republic of Germany.

出版信息

Virology. 1991 Oct;184(2):677-86. doi: 10.1016/0042-6822(91)90437-g.

DOI:10.1016/0042-6822(91)90437-g
PMID:1887589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7131244/
Abstract

The major subgenomic RNA of the calicivirus rabbit hemorrhagic disease virus which codes for the viral capsid protein has been cloned as cDNA. The nucleotide sequence of this mRNA was shown to be identical to the 3' terminal region of the genomic RNA. The 5' end of the mRNA corresponds to position 5296 of the genomic sequence; except for two differences the first 16 nucleotides of genomic and subgenomic RNAs are identical. After isolation from liver tissue viral genomic and subgenomic RNAs were found to be resistant to RNase degradation. This protection was due to RNA packaging into particles. Sucrose density gradient centrifugation of liver homogenates allowed separation of such particles containing either genomic RNA or subgenomic RNA. Genomic and subgenomic RNAs are protein-linked and for the genomic molecule this interaction is localized within the first 179 nucleotides. After radioactive labeling of purified RNA and subsequent RNase treatment a protein of 15 kDa was identified.

摘要

杯状病毒兔出血症病毒编码病毒衣壳蛋白的主要亚基因组RNA已被克隆为cDNA。该mRNA的核苷酸序列与基因组RNA的3'末端区域相同。mRNA的5'端对应于基因组序列的第5296位；除了两个差异外，基因组RNA和亚基因组RNA的前16个核苷酸是相同的。从肝组织中分离后，发现病毒基因组RNA和亚基因组RNA对RNase降解具有抗性。这种保护作用是由于RNA包装成颗粒。肝匀浆的蔗糖密度梯度离心可分离出含有基因组RNA或亚基因组RNA的颗粒。基因组RNA和亚基因组RNA与蛋白质相连，对于基因组分子，这种相互作用位于前179个核苷酸内。对纯化的RNA进行放射性标记并随后进行RNase处理后，鉴定出一种15 kDa的蛋白质。