Hahn R G, Jones A W, Billing B, Stalberg H P
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Acta Anaesthesiol Scand. 1991 Jul;35(5):393-7. doi: 10.1111/j.1399-6576.1991.tb03316.x.
If ethanol is added to the irrigant used during transurethral prostatic resection, the absorption of fluid can immediately be detected by measuring the ethanol concentration in the expired breath. To evaluate this method further, we studied the influence of chronic obstructive pulmonary disease (COPD) on the agreement between expired-breath and blood-ethanol concentrations. In 14 men with a mean age of 62 years (range 55-68), the concentrations of ethanol in whole blood and end-expired breath were measured at 12 exactly timed intervals before, during, and after an intravenous infusion of 0.6 g.kg-1 ethanol for 60 min. The pulmonary function was normal in seven of the subjects (control group) whereas the other seven suffered from severe COPD (study group). The results show that the accuracy and precision of breath-alcohol analysis to predict the blood-ethanol level were poorer during the infusion of ethanol than afterwards. However, at all times of sampling the estimation of blood-ethanol concentration indirectly by analysis of breath was not significantly different for COPD patients and the control group. We conclude that ethanol monitoring of irrigant absorption can be used successfully in patients with COPD.
如果在经尿道前列腺切除术中使用的灌洗液中添加乙醇，通过测量呼出气体中的乙醇浓度可立即检测到液体的吸收情况。为了进一步评估该方法，我们研究了慢性阻塞性肺疾病（COPD）对呼出气体乙醇浓度与血液乙醇浓度之间一致性的影响。在14名平均年龄为62岁（范围55 - 68岁）的男性中，在静脉输注0.6 g·kg-1乙醇60分钟之前、期间和之后，每隔12个精确计时的时间间隔测量全血和终末呼出气体中的乙醇浓度。其中7名受试者肺功能正常（对照组），另外7名患有重度COPD（研究组）。结果表明，与输注乙醇后相比，输注乙醇期间通过呼气酒精分析预测血液乙醇水平的准确性和精密度较差。然而，在所有采样时间，COPD患者和对照组通过分析呼气间接估计血液乙醇浓度并无显著差异。我们得出结论，乙醇监测灌洗液吸收情况可成功用于COPD患者。
