Newsome N A, Gross J
Invest Ophthalmol Vis Sci. 1977 Jan;16(1):21-31.
The incidence of perforation and deep ulceration of the alkali-burned rabbit cornea was substantially reduced by topical or parenteral administration of medroxyprogesterone. The mode of action of the hormone is probably at least in part related to its suppressive effects on production of tissue collagenase, as indicated by the considerable reduction in collagenolytic activity by living explants of the treated corneas.
通过局部或肠胃外给予甲羟孕酮，碱烧伤兔角膜穿孔和深层溃疡的发生率大幅降低。激素的作用方式可能至少部分与其对组织胶原酶产生的抑制作用有关，这一点从经处理角膜的活组织外植体的胶原olytic活性显著降低可以看出。
