重组1型金属蛋白酶组织抑制剂可抑制兔碱烧伤诱导的角膜溃疡形成。
Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali-burn-induced corneal ulceration in rabbits.
作者信息
Paterson C A, Wells J G, Koklitis P A, Higgs G A, Docherty A J
机构信息
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine 40292.
出版信息
Invest Ophthalmol Vis Sci. 1994 Feb;35(2):677-84.
PURPOSE
To test if recombinant tissue inhibitor of metalloproteinases (TIMP-1) was effective in reducing corneal ulceration after alkali injury to the rabbit cornea. The effect of TIMP-1 was compared with that of a proven synthetic metalloproteinase inhibitor.
METHODS
After a defined alkali injury to the rabbit cornea, a topical treatment regimen was followed for 24 days; one group was treated with vehicle only, a second group with recombinant TIMP-1, and a third group with the synthetic metalloproteinase inhibitor. Corneas were scored for ulceration during the 24-day period and the scores for the three groups were compared.
RESULTS
The incidence and progression of ulceration and perforation, in the alkali-burned corneas receiving treatment with recombinant TIMP-1 or the synthetic inhibitor, were significantly less than in corneas receiving vehicle treatment alone.
CONCLUSION
Recombinant TIMP-1 is as effective as a proven synthetic inhibitor in ameliorating corneal ulceration and perforation after an alkali injury.
目的
测试重组金属蛋白酶组织抑制剂（TIMP-1）是否能有效减少兔角膜碱烧伤后的角膜溃疡形成。将TIMP-1的效果与一种已证实的合成金属蛋白酶抑制剂的效果进行比较。
方法
对兔角膜进行特定的碱烧伤后，采用局部治疗方案持续24天；一组仅用赋形剂治疗，第二组用重组TIMP-1治疗，第三组用合成金属蛋白酶抑制剂治疗。在24天期间对角膜溃疡情况进行评分，并比较三组的评分。
结果
接受重组TIMP-1或合成抑制剂治疗的碱烧伤角膜中，溃疡和穿孔的发生率及进展明显低于仅接受赋形剂治疗的角膜。
结论
在改善碱烧伤后的角膜溃疡和穿孔方面，重组TIMP-1与一种已证实的合成抑制剂效果相当。
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