Sindern E, Stark E, Haas J, Steck A J
Department of Neurology and clinical Neurophysiology, Medical School of Hannover, Germany.
Acta Neurol Scand. 1991 Jun;83(6):399-402. doi: 10.1111/j.1600-0404.1991.tb03971.x.
Acute symmetric demyelinating polyneuropathy of the Guillain-Barré type is known in systemic lupus erythematosus (SLE). Chronic idiopathic demyelinating polyneuropathy (CIDP) has been reported rarely with SLE. A case is reported of CIDP accompanying SLE with autoantibodies against GM1- and GM3-gangliosides. There was no historical evidence to suggest SLE, and CIDP was the first manifestation of SLE. The 38-year-old patient had elevated CSF-protein, slow nerve conduction velocities, sural nerve biopsy revealed mixed axon loss with demyelination and CIDP white matter lesions were observed in magnetic resonance imaging, the GM1- and GM3-autoantibodies may play a role in the pathogenesis of CIDP in SLE.
格林-巴利型急性对称性脱髓鞘性多发性神经病在系统性红斑狼疮（SLE）中较为常见。慢性特发性脱髓鞘性多发性神经病（CIDP）与SLE相关的报道较为罕见。本文报道了1例伴有抗GM1和GM3神经节苷脂自身抗体的CIDP合并SLE患者。既往无提示SLE的病史证据，CIDP是SLE的首发表现。该38岁患者脑脊液蛋白升高，神经传导速度减慢，腓肠神经活检显示轴突混合性丢失伴脱髓鞘，磁共振成像观察到CIDP白质病变，GM1和GM3自身抗体可能在SLE中CIDP的发病机制中起作用。
