Koornstra P J, de Jong F I, Vlek L F, Marres E H, van Breda Vriesman P J
Department of Otolaryngology, Academic Hospital, Maastricht, The Netherlands.
Acta Otolaryngol. 1991;111(3):591-9. doi: 10.3109/00016489109138388.
By means of serial sectioning of the head and neck a paired, rod shaped, parachoanic lymphoid organ was identified in Lewis rats. Histological, ultrastructural studies and FACS analysis showed this organ to be a lympho-epithelial organ with high endothelial venules (HEV) and a preponderance of B over T and T helper over T suppressor cells. Consequently this organ resembles the pharyngeal tonsil of man, and it is called the Waldeyer ring equivalent (WRE). The lymphatic drainage of this organ occurs predominantly to the deep, and to a lesser extent to the superficial cervical lymph nodes. Migration studies with 51Cr labeled cells show that the WRE lymphoid cells migrate into the lymphoid organs with HEV (peripheral lymph nodes. Peyer patches and WRE). In this respect they resemble peripheral lymph node cells more than cells from the Peyer patches. Thus the WRE lymphoid tissue in the rat is undoubtedly involved in local oronasopharyngeal immune surveillance and may also contribute to mucosal and systemic immune responses.
通过对头颈部进行连续切片，在Lewis大鼠中发现了一个成对的、杆状的、咽旁淋巴器官。组织学、超微结构研究和流式细胞术分析表明，该器官是一个具有高内皮微静脉（HEV）的淋巴上皮器官，B细胞多于T细胞，辅助性T细胞多于抑制性T细胞。因此，该器官类似于人类的咽扁桃体，被称为Waldeyer环等效物（WRE）。该器官的淋巴引流主要至深部颈淋巴结，较少至浅部颈淋巴结。用51Cr标记细胞进行的迁移研究表明，WRE淋巴细胞迁移到具有HEV的淋巴器官（外周淋巴结、派尔集合淋巴结和WRE）中。在这方面，它们比来自派尔集合淋巴结的细胞更类似于外周淋巴结细胞。因此，大鼠中的WRE淋巴组织无疑参与了局部口鼻咽喉免疫监视，也可能有助于黏膜和全身免疫反应。
