Park H S, Kim J W, Hong C S
Department of Chest Medicine, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 1991 Mar;6(1):63-8. doi: 10.3346/jkms.1991.6.1.63.
Previous studies suggest that reactive dyes can induce IgE mediated bronchoconstrictions. To evaluate the significance of specific IgE and IgG antibodies in workers exposed to reactive dyes, we studied the prevalence of Black GR-specific IgG by enzyme linked immunosorbent assay, as well as Black GR-specific IgE by RAST, in 176 workers employed in 1 reactive dye factory and 4 neighboring factories. Six employees of reactive dye asthma who were working in factories near the reactive dye factories were noted. The prevalence of specific IgE antibodies in the neighboring factories was higher than in that of the reactive dye factory. The prevalence of specific IgG was highest in the reactive dye factory, and those of the neighboring factories were markedly lower. It was suggested that IgE mediated sensitization to reactive dye could have occurred in employees who were working in neighboring factories, and the prevalence of reactive dye-specific IgG antibody could be used as an in direct method of assessing the exposure of workers to reactive dye.
先前的研究表明，活性染料可诱发IgE介导的支气管收缩。为评估特异性IgE和IgG抗体在接触活性染料工人中的意义，我们采用酶联免疫吸附测定法研究了1家活性染料厂和4家邻近工厂的176名工人中黑色GR特异性IgG的流行情况，以及采用放射变应原吸附试验研究了黑色GR特异性IgE的流行情况。注意到有6名活性染料哮喘患者在活性染料厂附近的工厂工作。邻近工厂中特异性IgE抗体的流行率高于活性染料厂。特异性IgG的流行率在活性染料厂最高，而邻近工厂的则明显较低。提示在邻近工厂工作的员工中可能发生了IgE介导的对活性染料的致敏，活性染料特异性IgG抗体的流行率可作为评估工人接触活性染料的一种间接方法。
