Tse K S, Johnson A, Chan H, Chan-Yeung M
Allergy. 1985 Jul;40(5):314-20. doi: 10.1111/j.1398-9995.1985.tb00242.x.
The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non-asthmatic respiratory symptoms, and 26 were asymptomatic. Specific IgE antibodies to MDI were found in two workers (2.6%) and specific IgG antibodies, in five workers (6.6%). The prevalence of IgE and IgG antibodies was higher in the 10 subjects with asthma than in the non-asthmatic group. The prevalence of anti-paratolyl-monoisocyanate antibodies was not significantly different from that of anti-MDI antibodies, and both haptenic determinants displayed a high degree of cross-reactivity in the RAST inhibition test. The role of humoral immunological mechanisms in MDI-induced asthma is unclear in view of the rather low prevalence of these serum antibodies in this group of workers.
对一组76名职业性接触二苯基甲烷二异氰酸酯（MDI）的铸造工人进行了致敏率研究。10名工人有哮喘的临床证据，40名有非哮喘性呼吸道症状，26名无症状。在两名工人（2.6%）中发现了针对MDI的特异性IgE抗体，在五名工人（6.6%）中发现了特异性IgG抗体。哮喘的10名受试者中IgE和IgG抗体的患病率高于非哮喘组。抗对甲苯基单异氰酸酯抗体的患病率与抗MDI抗体的患病率无显著差异，并且在放射变应原吸附抑制试验中，两种半抗原决定簇均显示出高度交叉反应性。鉴于该组工人中这些血清抗体的患病率相当低，体液免疫机制在MDI诱发哮喘中的作用尚不清楚。
