Chadwick B, Addy M, Walker D M
Department of Child Dental Health, Dental School, University of Wales College of Medicine, Cardiff.
Br Dent J. 1991;171(3-4):83-7. doi: 10.1038/sj.bdj.4807615.
A number of compounds have been used in the management of recurrent oral ulceration, including antimicrobials. This was a double-blind placebo-controlled cross-over study to assess the value of a 0.1% hexetidine mouthwash in the management of minor aphthous ulceration and as an adjunct to oral hygiene. Forty patients with a catalogued history of ulceration took part. Patients were randomly allocated to active/placebo or vice versa order of mouthwashes, which were used as 15 ml volumes three times a day. Treatment periods were 6 weeks with a 3 week washout. During each period patients kept daily records of the number, site, and duration of ulcers, together with pain scores. Plaque and gingivitis were scored at baseline and end of treatment periods. Thirty-eight patients completed the study, with no significant treatment differences between active and placebo rinses on any ulcer parameter. Additionally, the hexetidine rinse provided no significant benefit to oral hygiene or gingival health. However, there was a significant period effect, with considerable ulcer improvements during the second period, irrespective of treatment. In conclusion, the hexetidine rinse appeared to offer no benefits to these patients, but professional supervision of ulcer treatment does appear to result in a worthwhile placebo effect.
许多化合物已被用于复发性口腔溃疡的治疗，包括抗菌药物。这是一项双盲安慰剂对照交叉研究，旨在评估0.1%洗必泰漱口水在治疗轻型阿弗他溃疡以及作为口腔卫生辅助措施方面的价值。40名有溃疡病史记录的患者参与了研究。患者被随机分配，按先使用活性药物/安慰剂或反之的顺序使用漱口水，每次用量为15毫升，每天3次。治疗期为6周，有3周的洗脱期。在每个治疗期内，患者每天记录溃疡的数量、部位、持续时间以及疼痛评分。在基线期和治疗期末对菌斑和牙龈炎进行评分。38名患者完成了研究，在任何溃疡参数方面，活性药物冲洗和安慰剂冲洗之间没有显著的治疗差异。此外，洗必泰冲洗对口腔卫生或牙龈健康没有显著益处。然而，存在显著的时期效应，无论治疗如何，在第二个治疗期溃疡有相当大的改善。总之，洗必泰冲洗似乎对这些患者没有益处，但溃疡治疗的专业监督似乎确实会产生值得的安慰剂效应。
