Eastman R C, Come S E, Strewler G J, Gorden P, Kahn C R
J Clin Endocrinol Metab. 1977 Jan;44(1):142-8. doi: 10.1210/jcem-44-1-142.
Two patients with advanced metastatic insulinoma are presented. Both failed to respond to streptozotocin and were refractory to other forms of chemotherapy. Therapy with adriamycin (Patient No. 1) and adriamycin plus 5-fluorouracil (Patient No. 2) led to significant decreases in insulin levels or measurable disease and both patients had clinical remissions lasting 5 to 7 months. Adriamycin may be effective in patients with advanced insulinoma unresponsive to conventional chemotherapy.
本文报告了两名晚期转移性胰岛素瘤患者。两名患者对链脲佐菌素均无反应，且对其他形式的化疗也耐药。使用阿霉素（1号患者）和阿霉素加5-氟尿嘧啶（2号患者）进行治疗后，胰岛素水平显著下降或疾病可测量，两名患者均有持续5至7个月的临床缓解。阿霉素可能对常规化疗无反应的晚期胰岛素瘤患者有效。
