Murphy B E
Department of Medicine, McGill University, Montreal, Canada.
J Steroid Biochem Mol Biol. 1991 Aug;39(2):239-44. doi: 10.1016/0960-0760(91)90069-h.
The hypercorticism frequently observed in major depression, unaccompanied by signs of Cushing's syndrome, is still poorly understood. One suicidal young woman, with very high cortisol levels and unusual resistance to dexamethasone suppression, is described. She was successfully treated with steroid suppressive drugs (aminoglutethimide, metyrapone), had a prompt and complete remission and has remained well for more than two years on no medication. This success prompted an on-going clinical trial of this therapy. The available drugs and a working hypothesis of their action are discussed.
在重度抑郁症中经常观察到的皮质醇增多症，且无库欣综合征的体征，目前仍了解甚少。本文描述了一名有自杀倾向的年轻女性，其皮质醇水平极高，对地塞米松抑制试验有异常抵抗。她接受类固醇抑制药物（氨鲁米特、美替拉酮）治疗成功，迅速完全缓解，且在未用药的情况下保持良好状态超过两年。这一成功促使正在进行该疗法的临床试验。文中讨论了可用药物及其作用的工作假设。
