Dupont A G, Coupez J M, Jensen P, Coupez-Lopinot R, Schoors D F, Hermanns P, Nicolas M
Department of Pharmacology, Vrije Universiteit Brussel, Belgium.
Cardiovasc Drugs Ther. 1991 Aug;5(4):701-7. doi: 10.1007/BF03029744.
Twelve patients with a mild to moderate essential hypertension were included in a double-blind, balanced, randomized placebo-controlled cross-over study to assess the efficacy and duration of action of a new slow-release formulation of diltiazem (300 mg) given once daily for 3 weeks. All office blood pressure measurements were done 24 hours after drug intake. In order to improve the accuracy of the trial, 24-hours non-invasive ambulatory blood pressure monitoring (Spacelabs 90207 system) were performed as well. Diltiazem significantly lowered supine and standing systolic and diastolic office blood pressure (by 16.9/12.7 mmHg and by 17.3/13.8 mmHg, respectively), without changing office heart rate. Diltiazem also significantly lowered ambulatory blood pressure measured over 24 hours, as well as ambulatory heart rate. The blood pressure lowering effect was most pronounced during the daytime period and did not reach statistical significance during the sleeping hours. The treatment was well tolerated, and there were no significant side effects. The results confirm the antihypertensive efficacy of diltiazem LP 300 mg once daily during the daytime and during the early morning blood pressure rise, without inducing nocturnal hypotension.
12名轻度至中度原发性高血压患者被纳入一项双盲、均衡、随机、安慰剂对照的交叉研究，以评估一种新的缓释地尔硫䓬制剂（300毫克）每日一次服用3周的疗效和作用持续时间。所有诊室血压测量均在服药24小时后进行。为提高试验准确性，还进行了24小时无创动态血压监测（Spacelabs 90207系统）。地尔硫䓬显著降低仰卧位和站立位的诊室收缩压和舒张压（分别降低16.9/12.7毫米汞柱和17.3/13.8毫米汞柱），且不改变诊室心率。地尔硫䓬还显著降低24小时动态血压以及动态心率。降压效果在白天最为显著，在睡眠时间未达到统计学意义。该治疗耐受性良好，无明显副作用。结果证实，地尔硫䓬300毫克每日一次在白天及清晨血压升高时具有降压效果，且不会导致夜间低血压。
