Satorre J, Antle C M, O'Sullivan R, White V A, Nugent R A, Rootman J
Department of Ophthalmology, Vancouver General Hospital, BC.
Can J Ophthalmol. 1991 Jun;26(4):174-95.
Orbital lesions characterized by granulomatous inflammation are a heterogeneous group of diseases of various causes with a common histopathological substrate involving aggregates of epithelioid cells. Forty-one patients (27 females and 14 males) with biopsy-proven granulomatous inflammation were seen at an orbital clinic between 1978 and 1989. The mean age at presentation was 40.2 (extremes 6 and 77) years. Two main clinical presentations were noted: painless, subacute or chronic mass effect, and tender, subacute inflammatory process. Six patients had secondary features that were infiltrative in character. The lesions were primarily located in the anterior superior orbit. In nearly half the patients the granulomatous reaction was confined to the orbit (predominantly ruptured dermoid and localized orbital sarcoid), and the remainder had either regional involvement (Wegener's granulomatosis or fibro-osseous process) or systemic involvement (sarcoidosis).
以肉芽肿性炎症为特征的眼眶病变是一组病因各异的异质性疾病，具有共同的组织病理学基础，涉及上皮样细胞聚集。1978年至1989年间，一家眼眶诊所共诊治了41例经活检证实为肉芽肿性炎症的患者（27例女性，14例男性）。就诊时的平均年龄为40.2岁（范围为6至77岁）。主要观察到两种临床表现：无痛性、亚急性或慢性肿块效应，以及压痛性、亚急性炎症过程。6例患者有浸润性的继发特征。病变主要位于眼眶前上部。近一半患者的肉芽肿反应局限于眼眶（主要是破裂的皮样囊肿和局限性眼眶结节病），其余患者则有局部受累（韦格纳肉芽肿或纤维骨病变）或全身受累（结节病）。
