Department of Ophthalmology, University Medical Center Utrecht, the Netherlands.
Clin Exp Rheumatol. 2011 Jan-Feb;29(1 Suppl 64):S35-9. Epub 2011 May 11.
Orbital manifestation of Wegener's granulomatosis is diverse and diagnosis is often difficult. This study aims to improve the diagnostic strategy in orbital Wegener.
A review of the diagnostic process in patients in whom a diagnosis of orbital WG was considered.
Thirty-three patients were analysed, consisting of 15 patients with orbital WG, 11 with idiopathic orbital inflammation, 6 with orbital sarcoidosis and one with aspergillosis. Diagnostic findings indicating orbital WG were ear/nose/throat involvement, multiple organ system involvement, a positive ANCA, and on histology vasculitis, whereas granulomatous inflammation without signs of vasculitis was more indicative of another orbital disease.
The diagnostic process of orbital WG should include CT scanning of the orbit and sinuses, ANCA blood testing, consultation of a rheumatologist, an ophthalmologist, and an ear-nose-throat specialist, and biopsy of an easily accessible, active inflammatory lesion.
韦格纳肉芽肿的眼眶表现多样，诊断常常较为困难。本研究旨在改进眼眶韦格纳的诊断策略。
回顾分析了被认为患有眼眶 WG 的患者的诊断过程。
分析了 33 例患者，其中 15 例为眼眶 WG，11 例为特发性眼眶炎症，6 例为眼眶结节病，1 例为曲霉病。提示眼眶 WG 的诊断发现包括耳鼻喉受累、多器官系统受累、ANCA 阳性，以及组织学上的血管炎，而无血管炎迹象的肉芽肿性炎症则更提示为另一种眼眶疾病。
眼眶 WG 的诊断过程应包括眼眶和鼻窦的 CT 扫描、ANCA 血液检测、风湿科、眼科和耳鼻喉科专家会诊，以及对易于触及的活动性炎症病变进行活检。
