Sewdarsen M, Vythilingum S, Jialal I, Becker P
Department of Medicine, R.K. Khan Hospital, Durban, South Africa.
Cardiology. 1991;78(4):348-56. doi: 10.1159/000174816.
The Indian (Asian) population in South Africa has a high rate of coronary artery disease. Fasting serum lipid and lipoprotein levels were measured in 620 consecutive male survivors of myocardial infarction and compared with those of 524 healthy male volunteer controls, and the presence of hypercholesterolaemia and hypertriglyceridaemia in the patient group was related to other non-lipid coronary risk factors. All survivors and controls were below age 61 years. Total cholesterol, triglyceride and low-density-lipoprotein cholesterol concentrations varied significantly with age both in patient and control groups, whereas high-density-lipoprotein (HDL) cholesterol did not vary with age in either group. Using the 90th-percentile age-adjusted values of controls for total cholesterol (7.1 mmol/l) and triglyceride (3.0 mmol/l) as cut-off points, 287 (46%) survivors were hyperlipidaemic. Hypercholesterolaemia with or without associated hypertriglyceridaemia was the commonest abnormality: 125 (20%) patients showed hypercholesterolaemia without associated hypertriglyceridaemia; 73 (12%) had both hypercholesterolaemia and hypertriglyceridaemia and 89 (14%) hypertriglyceridaemia without associated hypercholesterolaemia. The frequency of hyperlipidaemia did not vary with age. HDL cholesterol levels below 0.66 mmol/l (10th percentile) were observed in 131 (22%) survivors. Obesity was significantly more frequent among hypertriglyceridaemic survivors, whilst diabetes and hypertension were seen more frequently in survivors with combined hypercholesterolaemia and hypertriglyceridaemia. No significant difference was noted in the frequency of smoking and family history of coronary artery disease in hyperlipidaemia and normolipidaemic patients.
南非的印度（亚洲）人群冠心病发病率很高。对620名心肌梗死男性连续幸存者进行了空腹血脂和脂蛋白水平测量，并与524名健康男性志愿者对照进行比较，患者组中高胆固醇血症和高甘油三酯血症的存在与其他非脂质冠心病危险因素相关。所有幸存者和对照年龄均在61岁以下。患者组和对照组的总胆固醇、甘油三酯和低密度脂蛋白胆固醇浓度均随年龄显著变化，而高密度脂蛋白（HDL）胆固醇在两组中均不随年龄变化。以对照组年龄校正后的总胆固醇（7.1 mmol/l）和甘油三酯（3.0 mmol/l）第90百分位数作为切点，287名（46%）幸存者患有高脂血症。伴有或不伴有高甘油三酯血症的高胆固醇血症是最常见的异常情况：125名（20%）患者表现为无高甘油三酯血症的高胆固醇血症；73名（12%）既有高胆固醇血症又有高甘油三酯血症，89名（14%）有高甘油三酯血症但无高胆固醇血症。高脂血症的发生率不随年龄变化。131名（22%）幸存者的高密度脂蛋白胆固醇水平低于0.66 mmol/l（第10百分位数）。高甘油三酯血症幸存者中肥胖更为常见，而糖尿病和高血压在合并高胆固醇血症和高甘油三酯血症的幸存者中更为常见。高脂血症患者和血脂正常患者在吸烟频率和冠心病家族史方面未发现显著差异。
