印度农村地区脂蛋白脂质与高脂血症患病率

Lipoprotein lipids and the prevalence of hyperlipidaemia in rural India.

作者信息

Gupta R, Gupta H P, Kumar N, Joshi A K, Gupta V P

机构信息

Department of Medicine, Monilek Hospital and Research Centre, Jawahar Nagar, Jaipur, India.

出版信息

J Cardiovasc Risk. 1994 Aug;1(2):179-84. doi: 10.1177/174182679400100213.

DOI:10.1177/174182679400100213

PMID:7606632

Abstract

BACKGROUND

The prevalence of hyperlipidaemias has been inadequately studied in rural populations of developing countries. No significant data exist on the population levels of serum cholesterol, cholesterol subclasses or triglycerides in these countries.

METHODS

We studied fasting blood samples of 300 apparently healthy adults (202 men and 98 women, age range 20-73 years) randomly selected from a larger sample of 3148 individuals during a comprehensive cardiovascular risk-factor survey in Rajasthan, India. Levels of serum total cholesterol, its subfractions [low-density-lipoprotein (LDL) cholesterol, very-low-density-lipoprotein cholesterol and high-density-lipoprotein (HDL) cholesterol] and triglycerides were measured and correlated with age and anthropometric data.

RESULTS

The mean +/- SD serum total-cholesterol levels were 4.39 +/- 1.0 mmol/l in men and 4.37 +/- 1.0 mmol/l in women, the mean LDL-cholesterol levels 2.51 +/- 1.0 mmol/l in men and 2.62 +/- 0.9 mmol/l in women, the mean HDL-cholesterol levels 1.15 +/- 0.4 mmol/l in both mean and women and the mean fasting serum triglyceride levels 1.63 +/- 0.6 mmol/l in men and 1.48 +/- 0.7 mmol/l in women. Age correlated positively with total-cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride levels in both men and women. Levels of the cholesterol subtypes did not differ between the sexes (P > 0.01), although triglyceride levels were significantly higher in men (P < 0.01). Lipoprotein lipids did not correlate significantly with height, weight, body-mass index or waist:hip ratio. When classified according to the recommendations of the US National Cholesterol Education Program for the determination of the prevalence of hyperlipidaemia, 43 individuals (14.3%; men 14.4% and women 14.3%) had borderline high cholesterol levels (5.20-6.18 mmol/l) and 24 (8%; men 7.9% and women 8.2%) had high cholesterol levels (> or = 6.21 mmol/l). Forty-five participants (15%) had borderline high LDL-cholesterol levels (3.36-4.11 mmol/l) and 20 (6.7%) had high LDL-cholesterol levels (> or = 4.14 mmol/l); low HDL-cholesterol levels (< 0.9 mmol/L) were found in 89 (29.7%). Eighteen participants (6%) had mild hypertriglyceridaemia (2.82-5.64 mmol/l) and two (0.7%) had severe hypertriglyceridaemia (> 5.64 mmol/l).

CONCLUSION

Total-cholesterol and LDL-cholesterol levels are low in a rural Indian population, although an atherogenic lipid profile is present in a significant proportion.

摘要

背景

在发展中国家的农村人口中，高脂血症的患病率尚未得到充分研究。这些国家缺乏关于人群血清胆固醇、胆固醇亚类或甘油三酯水平的重要数据。

方法

在印度拉贾斯坦邦进行的一项全面心血管危险因素调查中，我们从3148人的较大样本中随机抽取了300名明显健康的成年人（202名男性和98名女性，年龄范围20 - 73岁）的空腹血样。测量血清总胆固醇、其亚组分[低密度脂蛋白（LDL）胆固醇、极低密度脂蛋白胆固醇和高密度脂蛋白（HDL）胆固醇]以及甘油三酯水平，并将其与年龄和人体测量数据相关联。

结果

男性血清总胆固醇水平的均值±标准差为4.39±1.0 mmol/l，女性为4.37±1.0 mmol/l；男性LDL胆固醇水平均值为2.51±1.0 mmol/l，女性为2.62±0.9 mmol/l；男性和女性的HDL胆固醇水平均值均为1.15±0.4 mmol/l；男性空腹血清甘油三酯水平均值为1.63±0.6 mmol/l，女性为1.48±0.7 mmol/l。年龄与男性和女性的总胆固醇、LDL胆固醇、HDL胆固醇和甘油三酯水平均呈正相关。胆固醇亚型水平在两性之间无差异（P>0.01），尽管男性的甘油三酯水平显著更高（P<0.01）。脂蛋白脂质与身高、体重、体重指数或腰臀比无显著相关性。根据美国国家胆固醇教育计划关于高脂血症患病率测定的建议进行分类，43人（14.3%；男性14.4%，女性14.3%）的胆固醇水平处于临界高水平（5.20 - 6.18 mmol/l），24人（8%；男性7.9%，女性8.2%）的胆固醇水平高（≥6.21 mmol/l）。45名参与者（15%）的LDL胆固醇水平处于临界高水平（3.36 - 4.11 mmol/l），20人（6.7%）的LDL胆固醇水平高（≥4.14 mmol/l）；89人（29.7%）的HDL胆固醇水平低（<0.9 mmol/L）。18名参与者（6%）有轻度高甘油三酯血症（2.82 - 5.64 mmol/l），2人（0.7%）有重度高甘油三酯血症（>5.64 mmol/l）。