一种与腮腺炎病毒相关的溶血素。
A hemolysin associated with the mumps virus.
作者信息
MORGAN H R, ENDERS J F, WAGLEY P F
出版信息
J Exp Med. 1948 Nov;88(5):503-14. doi: 10.1084/jem.88.5.503.
Abstract
- A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza virus. 3. The hemolysin is definitely inhibited by the serum of man and monkey convalescent from mumps, but only slightly by the serum of the acute phase. 4. The hemolysin is almost completely inactivated at 50 degrees C. after 10 minutes. It exhibits maximal activity at 37 degrees C. and is completely inactive at 4 degrees C. A pH range from about 7.0 to 8.0 allows for maximum activity. 5. Adsorption and elution of the hemolysin with red blood cells has been demonstrated. After elution of the hemolysin, the red blood cells exhibit an increased osmotic fragility. Similar treatment of red cells with influenza virus did not alter this property. 6. The relationship of the hemolysin to the hemagglutinin and the enzyme-like behavior of the former have been discussed.
摘要
- 感染腮腺炎病毒的鸡胚羊膜液和尿囊液中存在一种能引起人、鸡和绵羊红细胞溶血的因子。2. 在正常液体或感染流感病毒PR8或Lee B株的液体中未发现溶血素。3. 腮腺炎恢复期的人和猴的血清能明确抑制溶血素，但急性期血清的抑制作用较弱。4. 溶血素在50摄氏度下10分钟后几乎完全失活。它在37摄氏度时表现出最大活性，在4摄氏度时完全无活性。pH值在约7.0至8.0范围内活性最大。5. 已证明溶血素可被红细胞吸附和洗脱。溶血素洗脱后，红细胞的渗透脆性增加。用流感病毒对红细胞进行类似处理不会改变此特性。6. 已讨论了溶血素与血凝素的关系以及前者的类酶行为。
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