Palange P, Carlone S, Venditti M, Antony V B, Angelici E, Forte S, Sorice F, Serra P
II Patologia Medica, University of Rome La Sapienza, Italy.
Eur Respir J. 1991 Jun;4(6):639-42.
Alveolar lymphocytosis, in the face of blood lymphopenia, is a common finding among patients with AIDS. We studied by bronchoalveolar lavage (BAL), the alveolar cell profile of 43 human immuno deficiency virus (HIV) seropositive patients divided into three groups involving the advanced stages of the disease: group A (n = 9; CDC III), ambulatory individuals without systemic or respiratory symptoms; group B (n = 15; CDC IV) patients admitted for evaluation of fever of unknown origin (FUO) without pulmonary involvement; group C (n = 19; CDC IV), patients admitted for evaluation of an acute pulmonary condition. Sex, age and risk factor were comparable among the groups. Alveolar lymphocytosis was found in no group A patients, in 2 out of 15 group B patients (both with P. carinii lung infection) and in all group C patients, where pulmonary involvement was due to opportunistic infection or to nonspecific interstitial pneumonitis. Our findings suggest that in patients with advanced HIV infection alveolar lymphocytosis may be an expression of a concomitant process within the lungs either clinically manifest or inapparent, or possibly related to HIV primary lung involvement.
在血液淋巴细胞减少的情况下出现肺泡淋巴细胞增多，是艾滋病患者的常见表现。我们通过支气管肺泡灌洗（BAL）研究了43例人类免疫缺陷病毒（HIV）血清阳性患者的肺泡细胞情况，这些患者被分为三组，均处于疾病晚期：A组（n = 9；疾病控制中心III级），无全身或呼吸道症状的门诊患者；B组（n = 15；疾病控制中心IV级），因不明原因发热（FUO）入院且无肺部受累的患者；C组（n = 19；疾病控制中心IV级），因急性肺部疾病入院的患者。三组患者的性别、年龄和危险因素具有可比性。A组患者均未发现肺泡淋巴细胞增多，B组15例患者中有2例（均患有卡氏肺孢子虫肺部感染）出现肺泡淋巴细胞增多，C组所有患者均出现肺泡淋巴细胞增多，其肺部受累是由机会性感染或非特异性间质性肺炎引起的。我们的研究结果表明，在晚期HIV感染患者中，肺泡淋巴细胞增多可能是肺部伴随进程的一种表现，该进程可能是临床显性的，也可能是隐性的，或者可能与HIV原发性肺部受累有关。
