Schmidt T, Leipert K P, Fellbaum C
Augenklinik und Poliklinik, Klinikum rechts der Isar.
Fortschr Ophthalmol. 1991;88(3):279-82.
For a few years new Chondroplast has been available as a ready-to-use product in a variety of different shapes and sizes. The material is obtained from bovine cartilage and is made antigen-free and stable against decomposition by treatment with glutaraldehyde and irradiation. To date we have used Chondroplast for lid stabilization in 9 eyes with very slack entropion or ectropion. For tarsusplasty secondary to tumor resection we chose Chondroplast for seven eyes. A thin 0.5-mm-thick lamella was cut out of the original material and positioned in a preformed pocket between the orbicularis muscle and the skin and conjunctiva and then fixed with Vicryl sutures. Corrective of eyelid malposition was combined with pentagonal excision for ectropion, or resection of the orbicularis muscle for entropion. In plastic lid replacement the material was sutured to the existing wound edges of the lid margin and covered posteriorly with conjunctiva and anteriorly with advancement or transposed flaps. In all patients the implant took well, and there were no complications during wound healing. The cosmetic and functional results were satisfactory. The largest post-operation follow-up time was over 1 year. In one case--1 year after resection of a lower eyelid basalioma--we had the opportunity to examine histologically the tissue in the area of a Chondroplast implant. We performed this biopsy excision because of a suspected recurrence. Macroscopically the implanted cartilage lamella was surrounded by a barely vascularized capsule. Histologically we found a non-vital cartilage implant surrounded by a mainly fibrotic connective tissue capsule. In only a few places was there evidence of a slight reaction to the foreign body but without substantial inflammation activity. There was also no histological indication of resorption of the implant.
几年来,新型软骨修复材料(Chondroplast)已有即用型产品,有各种不同的形状和尺寸。该材料取自牛软骨,经戊二醛处理和辐照后,成为无抗原且抗分解稳定的材料。迄今为止,我们已将软骨修复材料用于9例睑裂极度松弛的睑内翻或睑外翻患者的眼睑固定。对于肿瘤切除后继发的睑板成形术,我们为7只眼选择了软骨修复材料。从原始材料上切下一片0.5毫米厚的薄片,置于眼轮匝肌与皮肤及结膜之间预先形成的囊袋中,然后用薇乔缝线固定。眼睑位置异常的矫正联合睑外翻的五边形切除术或睑内翻的眼轮匝肌切除术。在眼睑整形置换术中,将材料缝合到睑缘现有的伤口边缘,后部用结膜覆盖,前部用推进或转移皮瓣覆盖。所有患者的植入物均顺利愈合,伤口愈合期间无并发症。美容和功能效果令人满意。最长的术后随访时间超过1年。在1例病例中——下睑基底细胞瘤切除术后1年——我们有机会对软骨修复材料植入区域的组织进行组织学检查。由于怀疑复发,我们进行了此次活检切除。肉眼可见植入的软骨薄片被一个几乎无血管的囊膜包围。组织学检查发现,植入的软骨已无活力,周围主要是纤维化的结缔组织囊膜。仅在少数部位有对异物轻微反应的迹象,但无明显炎症活动。也没有组织学证据表明植入物有吸收现象。