Rice T, Vogler G P, Laskarzewski P M, Perry T S, Rao D C
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110.
Hum Biol. 1991 Aug;63(4):419-39.
The familial aggregation of lipids [total cholesterol (CH) and triglyceride (TG)] and lipoproteins [high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL)] was investigated in families ascertained through both random and nonrandom probands in the Minnesota Lipid Research Clinic Family Study. Nonrandom proband ascertainment was based on single selection through truncation for hyperlipidemia at an earlier screening. A path model was used to investigate the nature of familial resemblance using appropriate adjustments for ascertainment and to determine whether random and hyperlipidemic samples are heterogeneous with regard to the multifactorial model. The results suggest that parameter estimates are consistent with those from previous studies in which only random families were used and that random and nonrandom samples are homogeneous with regard to the path model for CH and LDL. However, for TG and HDL the random and hyperlipidemic samples are significantly heterogeneous. This heterogeneity would be observed if familial hypertriglyceridemia and/or familial hypoalphalipoproteinemia segregates predominantly in the hyperlipidemic rather than in the random sample, as on might expect.
在明尼苏达脂质研究诊所家族研究中，通过随机和非随机先证者确定的家族中，研究了脂质[总胆固醇（CH）和甘油三酯（TG）]以及脂蛋白[高密度脂蛋白胆固醇（HDL）和低密度脂蛋白胆固醇（LDL）]的家族聚集情况。非随机先证者的确定是基于早期筛查时通过截断高脂血症进行的单一选择。使用路径模型来研究家族相似性的本质，并对确定方法进行适当调整，以确定随机样本和高脂血症样本在多因素模型方面是否存在异质性。结果表明，参数估计与之前仅使用随机家族的研究结果一致，并且在CH和LDL的路径模型方面，随机样本和非随机样本是同质的。然而，对于TG和HDL，随机样本和高脂血症样本存在显著的异质性。如果家族性高甘油三酯血症和/或家族性低α脂蛋白血症主要在高脂血症样本而非随机样本中分离，就会观察到这种异质性，正如人们所预期的那样。
