Polonsky S M, Simbartl L A, Sprecher D L
Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati College of Medicine, Ohio.
Pediatrics. 1994 Dec;94(6 Pt 1):824-31.
To determine whether lipid disorders can be predicted in parents after such disorders are identified initially in their children. Although this relation has been well determined for children with high cholesterol or low-density lipoprotein cholesterol (LDL-C), it has not been as well described for disorders involving triglycerides (TG) or high-density lipoprotein cholesterol (HDL-C), or their interaction with LDL-C.
Serum lipid values were obtained from 232 families in the comparison population of a large genetics study. Subjects were classified into four groups based on their lipid status: 1) isolated LDL-C disorder, defined by a high LDL-C level and normal TG and HDL-C levels; 2) isolated TG/HDL-C disorder, defined by either high TG, low HDL-C, or both, and normal LDL-C; 3) combined disorder, defined by high LDL-C in addition to either high TG, low HDL-C, or both; and 4) normal, defined by the absence of any of the above disorders. The frequencies of these disorders were noted in both parents and children, and logistic regression analyses were conducted to determine whether the presence of these disorders in at least one child in the family could predict similar disorders in the parents.
Children with isolated LDL-C or TG/HDL-C disorder were more likely to have parents with the same disorder as themselves (P = .002 and P = .04, respectively). Children with the combined disorder were more likely to have parents with any lipid disorder (P = .009), but especially isolated LDL-C (P = .002) and isolated TG/HDL-C (P = .05).
A classification scheme defining disorders of TG and HDL-C, LDL-C, or a combination can be useful for predicting lipid disorders in parents after such disorders are identified initially in their children.
确定在儿童首次被诊断出脂质紊乱后，其父母是否也会出现脂质紊乱。尽管高胆固醇或低密度脂蛋白胆固醇（LDL-C）血症儿童与其父母之间的这种关系已得到充分证实，但对于涉及甘油三酯（TG）或高密度脂蛋白胆固醇（HDL-C）的紊乱情况，或它们与LDL-C的相互作用，相关描述较少。
从一项大型遗传学研究的对照人群中的232个家庭获取血清脂质值。根据脂质状况将受试者分为四组：1）单纯LDL-C紊乱，定义为LDL-C水平高而TG和HDL-C水平正常；2）单纯TG/HDL-C紊乱，定义为TG高、HDL-C低或两者皆有，且LDL-C正常；3）混合紊乱，定义为除TG高、HDL-C低或两者皆有外，LDL-C也高；4）正常，定义为不存在上述任何紊乱情况。记录父母和孩子中这些紊乱情况的发生率，并进行逻辑回归分析，以确定家庭中至少有一个孩子出现这些紊乱情况是否能预测其父母也会出现类似紊乱。
患有单纯LDL-C或TG/HDL-C紊乱的儿童，其父母患相同紊乱的可能性更大（分别为P = 0.002和P = 0.04）。患有混合紊乱的儿童，其父母患任何脂质紊乱的可能性更大（P = 0.009），尤其是单纯LDL-C紊乱（P = 0.002）和单纯TG/HDL-C紊乱（P = 0.05）。
一种定义TG和HDL-C、LDL-C紊乱或两者组合的分类方案，对于在儿童首次被诊断出脂质紊乱后预测其父母是否会出现脂质紊乱可能有用。
