Nandi A, Chatterjee I B
Department of Biochemistry, University College of Science, Calcutta, India.
Indian J Exp Biol. 1991 Jun;29(6):574-8.
There is a correlation between phylogeny and the activities of L-gulonolactone oxidase (LGO), the key enzyme responsible for ascorbic acid (AH2) synthesis in animals and total xanthine oxidase and dehydrogenase [XOD(D/O)], the enzyme responsible for the production of endogenous superoxide radical (O2-.). LGO appears in the kidneys of amphibians and reptiles but livers of mammals. XOD(D/O) also is present mainly in the kidneys of amphibians and reptiles and livers of mammals. AH2 is a potential scavenger of O2-. and it appears that tissue specific expression of LGO takes place to counteract the endogenous O2-. toxicity. The interrelation of XOD(D/O) and LGO was also observed in the liver of rats during prenatal to postnatal development.
在系统发育与L-古洛糖酸内酯氧化酶（LGO）的活性之间存在相关性，LGO是动物体内负责合成抗坏血酸（AH2）的关键酶，与总黄嘌呤氧化酶和脱氢酶[XOD（D/O）]也存在相关性，XOD（D/O）是负责产生内源性超氧自由基（O2-。）的酶。LGO出现在两栖动物和爬行动物的肾脏中，但在哺乳动物的肝脏中出现。XOD（D/O）也主要存在于两栖动物和爬行动物的肾脏以及哺乳动物的肝脏中。AH2是O2-。的潜在清除剂，似乎LGO的组织特异性表达是为了抵消内源性O2-。的毒性。在大鼠从产前到产后发育过程中，也观察到了XOD（D/O）和LGO之间的相互关系。
