大鼠纤维肉瘤和腺癌细胞的形态学、变形能力及微血管停滞
The morphology, deformability and microvascular arrest of rat fibrosarcoma and adenocarcinoma cells.
作者信息
Nannmark U, Bagge U, Johansson B R, Skolnik G
机构信息
Department of Anatomy, University of Göteborg, Sweden.
出版信息
J Cancer Res Clin Oncol. 1991;117(5):431-4. doi: 10.1007/BF01612763.
The deformation and flow properties of tumour cells may play a role in their arrest in the microvasculature of different organs. In the present investigation the morphology, deformability and microvascular arrest in the liver of rat fibrosarcoma cells (FSCs) and adenocarcinoma cells (ACCs) were compared using electron microscopy, deformability measurements in narrow glass pipettes and isotope-labelling techniques. The ACCs had a larger mean diameter (13.9 microns) than the FSCs (10.9 microns) and showed a slower rate of deformation into 6.5 microns glass pipettes. A significantly larger percentage of ACCSs (52.4%) than of FSCs (19.9%) remained in the livers 5 min after intraportal injection. The results indicate that for the particular tumour cells studied here, there exists a relationship between cell deformability and the tendency for microvascular trapping in the liver, i.e. less deformable cells have a greater tendency for retention in the liver.
肿瘤细胞的变形和流动特性可能在其滞留于不同器官的微血管中发挥作用。在本研究中，使用电子显微镜、窄玻璃微管中的变形性测量以及同位素标记技术，比较了大鼠纤维肉瘤细胞（FSCs）和腺癌细胞（ACCs）在肝脏中的形态、变形性和微血管滞留情况。ACCs的平均直径（13.9微米）大于FSCs（10.9微米），并且在变形进入6.5微米玻璃微管时显示出较慢的变形速率。门静脉内注射5分钟后，留在肝脏中的ACCs（52.4%）的比例显著高于FSCs（19.9%）。结果表明，对于此处研究的特定肿瘤细胞，细胞变形性与肝脏中微血管滞留倾向之间存在关联，即变形性较小的细胞在肝脏中滞留的倾向更大。
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