血小板减少症和抗血清素治疗对循环肿瘤细胞着床的影响。大鼠的活体荧光显微镜、电子显微镜及同位素研究。
The effect of thrombocytopenia and antiserotonin treatment on the lodgement of circulating tumor cells. A vital fluorescence microscopic, electron microscopic and isotope study in the rat.
作者信息
Skolnik G, Ericson L E, Bagge U
出版信息
J Cancer Res Clin Oncol. 1983;105(1):30-7. doi: 10.1007/BF00391829.
Abstract
The hepatic lodgement of intraportally injected fibrosarcoma cells was analysed with a combination of vital fluorescence microscopic, electron microscopic and isotope techniques in normal, thrombocytopenic and antiserotonin treated (Ketanserin) rats. Ketanserin had no effect on the initial arrest of the tumor cells, as measured 5 min after tumor cell injection, which is in analogy with our previous results on thrombocytopenia. Three hours after injection, the number of lodged tumor cells was significantly reduced by both thrombocytopenia and Ketanserin treatment. Thrombocytopenia was more efficient in reducing tumor cell lodgement than antiserotonin treatment. The in vivo and electron microscopic observations indicated that the reduction of tumor cell lodgement was due to an increased destruction of tumor cells. The similar effects of Ketanserin and thrombocytopenia suggest that serotonin, when released from platelets activated in the presence of tumor cells, increases the survival of fibrosarcoma cells lodged in the liver.
摘要
采用活体荧光显微镜、电子显微镜和同位素技术相结合的方法，对正常、血小板减少以及抗血清素治疗（酮色林）的大鼠经门静脉注射纤维肉瘤细胞后的肝脏潴留情况进行了分析。肿瘤细胞注射5分钟后测量发现，酮色林对肿瘤细胞的初始滞留无影响，这与我们之前关于血小板减少症的研究结果相似。注射3小时后，血小板减少症和酮色林治疗均显著减少了滞留的肿瘤细胞数量。血小板减少症在减少肿瘤细胞潴留方面比抗血清素治疗更有效。体内和电子显微镜观察表明，肿瘤细胞潴留的减少是由于肿瘤细胞破坏增加所致。酮色林和血小板减少症的类似作用表明，当血清素从在肿瘤细胞存在下激活的血小板中释放时，会增加滞留在肝脏中的纤维肉瘤细胞的存活率。
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本文引用的文献
1
Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber.在兔耳室体内观察到的转移形成的发病机制。
AMA Arch Pathol. 1958 Oct;66(4):550-68.
2
Nigrosin as a dye for differentiating live and dead ascites cells.黑色素作为区分活腹水细胞和死腹水细胞的染料。
Exp Cell Res. 1958 Aug;15(1):112-7. doi: 10.1016/0014-4827(58)90067-3.
3
Studies on mechanisms involved in metastasis formation from circulating tumor cells. Factors influencing tumor cell lodgement during normal and post-traumatic conditions.循环肿瘤细胞形成转移的机制研究。正常及创伤后影响肿瘤细胞着床的因素。
J Cancer Res Clin Oncol. 1980;97(3):249-56. doi: 10.1007/BF00405776.
4
Eosinophil-mediated mammalian tumor cell cytotoxicity: role of the peroxidase system.嗜酸性粒细胞介导的哺乳动物肿瘤细胞细胞毒性：过氧化物酶系统的作用。
J Immunol. 1980 Apr;124(4):1949-53.
5
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6
Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.新型5-羟色胺2受体拮抗剂R 41 468的受体结合情况
Life Sci. 1981 Mar 2;28(9):1015-22. doi: 10.1016/0024-3205(81)90747-5.
7
8
The influence of trauma, Dextran 1000, and Dextran 40 on the lodgement of circulating tumor cells.创伤、右旋糖酐1000及右旋糖酐40对循环肿瘤细胞黏附的影响
J Cancer Res Clin Oncol. 1980;97(3):241-8. doi: 10.1007/BF00405775.
9
Action of heparin and plasminogen inhibitor (EACA) on metastatic tumour spread in an isologous system.肝素与纤溶酶原抑制剂（6-氨基己酸）对同种系统中转移性肿瘤扩散的作用
Acta Pathol Microbiol Scand. 1965;65(3):395-404. doi: 10.1111/apm.1965.65.3.395.
10
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J Physiol. 1969 Apr;201(2):409-23. doi: 10.1113/jphysiol.1969.sp008763.
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