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中耳腺瘤：具有黏液性和神经内分泌混合分化的肿瘤。

Middle ear adenoma: tumour of mixed mucinous and neuroendocrine differentiation.

作者信息

Hale R J, McMahon R F, Whittaker J S

机构信息

Department of Histopathology, Wythenshawe Hospital.

出版信息

J Clin Pathol. 1991 Aug;44(8):652-4. doi: 10.1136/jcp.44.8.652.

DOI:10.1136/jcp.44.8.652
PMID:1890199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC496756/
Abstract

Two cases of progressive hearing loss due to middle ear tumours are described. The histological characteristics numbered intraluminal mucin production and neuroendocrine features, as shown by argyrophilia and ultrastructural demonstration of dense core granules. These tumours have been known by many different names, reflecting the controversies relating to their presumed histogenesis and differentiation. The currently preferred designation is middle ear adenoma, and these two cases provide further evidence for dual lines of differentiation.

摘要

本文描述了两例因中耳肿瘤导致的进行性听力损失病例。组织学特征包括腔内粘蛋白产生和神经内分泌特征，嗜银染色及致密核心颗粒的超微结构显示可证实这些特征。这些肿瘤有许多不同的名称，反映了关于其假定的组织发生和分化的争议。目前首选的名称是中耳腺瘤，这两个病例为双重分化谱系提供了进一步的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/8435cffea0fe/jclinpath00410-0037-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/3b6affc086b7/jclinpath00410-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/6e95e7233d92/jclinpath00410-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/2b4564245e0c/jclinpath00410-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/8435cffea0fe/jclinpath00410-0037-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/3b6affc086b7/jclinpath00410-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/6e95e7233d92/jclinpath00410-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/2b4564245e0c/jclinpath00410-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8041/496756/8435cffea0fe/jclinpath00410-0037-c.jpg

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Neuroendocrine neoplasms of the head and neck: some suggestions for the new WHO classification of head and neck tumors.头颈部神经内分泌肿瘤：关于新版《世界卫生组织头颈部肿瘤分类》的一些建议

本文引用的文献

1
Middle ear adenoma. A cytologically uniform neoplasm displaying a variety of architectural patterns.中耳腺瘤。一种细胞学形态单一的肿瘤，呈现出多种结构模式。
Am J Surg Pathol. 1984 Sep;8(9):677-85.
2
Carcinoid tumor of the middle ear.中耳类癌肿瘤。
Am J Clin Pathol. 1980 Jun;73(6):816-23. doi: 10.1093/ajcp/73.6.816.
3
Carcinoid tumour of the middle ear associated with systemic symptoms.中耳类癌瘤伴全身症状
Head Neck Pathol. 2014 Mar;8(1):24-32. doi: 10.1007/s12105-014-0531-y. Epub 2014 Mar 5.
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Carcinoid tumor of the middle ear in a 28-year-old patient.
Pathol Oncol Res. 1998;4(1):40-3. doi: 10.1007/BF02904694.
J Laryngol Otol. 1987 May;101(5):480-6. doi: 10.1017/s002221510010204x.
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Carcinoid tumors of the middle ear.
Am J Clin Pathol. 1987 May;87(5):592-600. doi: 10.1093/ajcp/87.5.592.
5
Carcinoid tumour of the middle ear.中耳类癌肿瘤。
J Laryngol Otol. 1989 Jan;103(1):86-91. doi: 10.1017/s0022215100108102.
6
Middle ear adenoma. A tumor displaying mucinous and neuroendocrine differentiation.
Am J Surg Pathol. 1989 Oct;13(10):838-47.
7
Middle ear neoplasms showing adenomatous and neuroendocrine components.显示腺瘤样和神经内分泌成分的中耳肿瘤。
J Laryngol Otol. 1989 Apr;103(4):404-7. doi: 10.1017/s0022215100109065.
8
Carcinoid tumour of the middle ear. A morphological and immunohistochemical study with comments on histogenesis and differential diagnosis.
Pathol Res Pract. 1989 Oct;185(4):496-503; discussion 504-5. doi: 10.1016/S0344-0338(89)80073-1.
9
Benign adenomatous neoplasm (adenoma) of the middle ear.
Clin Otolaryngol Allied Sci. 1976;1(1):17-26. doi: 10.1111/j.1365-2273.1976.tb00637.x.