Murphy G F, Pilch B Z, Dickersin G R, Goodman M L, Nadol J B
Am J Clin Pathol. 1980 Jun;73(6):816-23. doi: 10.1093/ajcp/73.6.816.
A primary tumor of the middle ear with histologic, histochemical, and ultrastructural features of a neuroendocrine neoplasm is described. This neoplasm superficially resembles the so-called adenomatous tumor of the middle ear, and potential relationships and differences between these tumors are discussed. Although the histogenesis of the carcinoid tumor of the middle ear is not well understood, it most likely originates from pre-existing neuroendocrine cells or a primitive precursor cell. This neoplasm should be considered in the differential diagnosis when biologically low-grade tumors with prominent acinar or trabecular architectures are encountered in the middle ear. Since the carcinoid tumor of the middle ear is presumably of foregut derivation, stains for argyrophilic granules and electron-microscopic identification of neurosecretory granules are important diagnostic aids.
本文描述了一例具有神经内分泌肿瘤组织学、组织化学和超微结构特征的中耳原发性肿瘤。该肿瘤表面上类似于所谓的中耳腺瘤性肿瘤，并讨论了这些肿瘤之间的潜在关系和差异。尽管中耳类癌的组织发生尚不清楚，但它很可能起源于预先存在的神经内分泌细胞或原始前体细胞。当中耳遇到具有突出腺泡或小梁结构的生物学低级别肿瘤时，应考虑该肿瘤进行鉴别诊断。由于中耳类癌可能起源于前肠，嗜银颗粒染色和神经分泌颗粒的电子显微镜鉴定是重要的诊断辅助手段。
