Coiro V, Volpi R, Cavazzini U, Bertoni P, Corradi A, Bianconi L, Davoli C, Rossi G, Chiodera P
School of Medicine, University of Parma, Italy.
J Gerontol. 1991 Sep;46(5):M155-8. doi: 10.1093/geronj/46.5.m155.
In order to establish whether the age-related reduced growth hormone (GH) responsiveness to GH-releasing hormone (GHRH) could be improved by treatment with low amounts of theophylline, a drug mainly acting through cyclic adenosine 3', 5'-monophosphate (cAMP), and calcium-mediated mechanisms, eight adult subjects (aged 20-37) and eight elderly men (aged 64-79) were tested with GHRH (50 micrograms in an iv bolus), theophylline (1.67 mg/min for 3 h), or the combination of both drugs. The GH response to GHRH was significantly lower in the older than in the younger group (mean peaks were 4.5 and 7.5 times higher than baseline, respectively). Theophylline did not change basal GH levels in any subjects and GHRH-induced GH rise in the younger group, whereas it restored normal GH responses to GHRH in the older subjects (mean peak responses were eight times higher than baseline in both groups). These data show that in elderly subjects the mechanism underlying the GHRH-induced GH secretion may be fully activated by GHRH during treatment with low amounts of theophylline.
为了确定低剂量茶碱治疗是否能改善与年龄相关的生长激素（GH）对生长激素释放激素（GHRH）反应性降低的情况，茶碱是一种主要通过环磷酸腺苷（cAMP）和钙介导机制起作用的药物，对8名成年受试者（年龄20 - 37岁）和8名老年男性（年龄64 - 79岁）进行了GHRH（静脉推注50微克）、茶碱（1.67毫克/分钟，持续3小时）或两种药物联合使用的测试。老年组对GHRH的GH反应明显低于年轻组（平均峰值分别比基线高4.5倍和7.5倍）。茶碱对任何受试者的基础GH水平以及年轻组中GHRH诱导的GH升高均无影响，而在老年受试者中它恢复了对GHRH的正常GH反应（两组的平均峰值反应均比基线高8倍）。这些数据表明，在老年受试者中，低剂量茶碱治疗期间，GHRH诱导GH分泌的潜在机制可能被GHRH完全激活。
