水泡性口炎病毒的利福平敏感突变体：蛋白质与RNA合成
Rifampin-susceptible mutant of vesicular stomatitis virus: protein and RNA synthesis.
作者信息
Moreau M C, Sanzey B
出版信息
J Virol. 1977 Jan;21(1):41-53. doi: 10.1128/JVI.21.1.41-53.1977.
Abstract
A rifampin-susceptible strain (VSV Rif+) was selected from the wild vesicular stomatitis virus (VSV) population unsusceptible to rifampin. The VSV Rif+ was blocked in its intracellular replication in the presence of rifampin. In cells, rifampin affected primarily VSV Rif+ transcription, but to a different extent than in a cell-free system. In addition, a decrease in the amount of VSV Rif+ protein M was detected, linked to a stimulation of protein NS. In the absence of rifampin, protein M, although synthesized, was not immediately incorporated into the cell membrane. An interpretation of these observations is proposed.
摘要
从对利福平不敏感的野生水疱性口炎病毒（VSV）群体中筛选出一株对利福平敏感的毒株（VSV Rif+）。在利福平存在的情况下，VSV Rif+在细胞内的复制受到阻断。在细胞中，利福平主要影响VSV Rif+的转录，但程度与无细胞系统不同。此外，检测到VSV Rif+蛋白M的量减少，这与蛋白NS的增加有关。在没有利福平的情况下，蛋白M虽然合成了，但没有立即整合到细胞膜中。本文对这些观察结果提出了解释。
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