Nakamura H, Tokunaga S, Sadamori N, Tomonaga M, Ichimaru M, Kinoshita K, Yanai M, Tsuji Y, Shimizu S
Department of Internal Medicine, Atomic Disease Institute, Nagasaki University School of Medicine.
Rinsho Ketsueki. 1991 Jun;32(6):690-2.
We performed cytogenetic studies and breakpoint cluster region (bcr) rearrangement analysis in two cases of juvenile chronic myeloid leukemia (JCML) which is special type of chronic myeloid leukemia (CML). Case 1 (8-month-old male) and case 2 (3-month-old female) showed clinical and hematologic manifestations similar to CML. Each of case 1 and 2 had normal karyotype and no bcr rearrangement. These findings suggest that JCML is a different heterogeneous disorder from that of adult CML.
