Toyoshima H, Hori M, Yoshida H
Department of Dermatology, Nagasaki University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1991 Apr;101(5):527-31.
To know the variation of DNA contents of seborrheic keratosis, keratoacanthoma, actinic keratosis, and Bowen's disease, cytophotometric assay was used. As the results, following findings were obtained. 1. DNA index of actinic keratosis was higher than those of seborrheic keratosis and keratoacanthoma. 2. DNA index of Bowen's disease was higher than that of seborrheic keratosis. 3. Polyploid cell population (greater than 6C) of keratoacanthoma was higher than that of seborrheic keratosis. 4. Polyploid cell populations (greater than GC) of carcinoma in site (actinic keratosis, Bowen's disease) were higher than that of keratoacanthoma . These date suggested that polyploid cell population and DNA index reflect grade of malignancy of tumor developed from keratinocytes. A clinic keratosis and Bowen's disease revealed almost the same DNA pattern. And the difference of polyploid cell population of keratoacanthoma++ ++ and seborrheic keratosis suggested the difference of the biological activity of them.
为了解脂溢性角化病、角化棘皮瘤、光化性角化病和鲍温病的DNA含量变化，采用了细胞光度测定法。结果如下：1. 光化性角化病的DNA指数高于脂溢性角化病和角化棘皮瘤。2. 鲍温病的DNA指数高于脂溢性角化病。3. 角化棘皮瘤的多倍体细胞群（大于6C）高于脂溢性角化病。4. 原位癌（光化性角化病、鲍温病）的多倍体细胞群（大于GC）高于角化棘皮瘤。这些数据表明，多倍体细胞群和DNA指数反映了由角质形成细胞发展而来的肿瘤的恶性程度。临床角化病和鲍温病显示出几乎相同的DNA模式。角化棘皮瘤和脂溢性角化病多倍体细胞群的差异表明了它们生物学活性的差异。
