Pikaart M, Irving J, Villeponteau B
Institute of Gerontology, University of Michigan, Ann Arbor.
Mech Ageing Dev. 1991 Jun 14;59(1-2):189-95. doi: 10.1016/0047-6374(91)90084-d.
Previous studies have implicated histone H5 dephosphorylation as a causal factor in genetic inactivation and chromatin condensation during erythroid senescence in adult chickens. We show that histone H5 phosphorylation declines in two stages as various cohorts of erythroid cells senesce in chick embryos. The first decline occurs between 5 and 6 days and coincides with the senescence of primitive erythrocytes. The second decline in H5 phosphorylation occurs between 17 and 19 days of chicken development, when the definitive erythrocytes undergo senescence and chromatin condensation. These results point to a role for histone dephosphorylation during the programmed senescence of erythroid cells.
先前的研究表明，组蛋白H5去磷酸化是成年鸡红细胞衰老过程中基因失活和染色质凝聚的一个致病因素。我们发现，随着鸡胚中不同批次的红细胞衰老，组蛋白H5磷酸化在两个阶段下降。第一次下降发生在5至6天之间，与原始红细胞的衰老同时发生。H5磷酸化的第二次下降发生在鸡发育的17至19天之间，此时成熟红细胞经历衰老和染色质凝聚。这些结果表明组蛋白去磷酸化在红细胞程序性衰老过程中发挥作用。
