Kwak S, Aizawa H, Ishida M, Shinozaki H
National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Kodaira, Tokyo, Japan.
Life Sci. 1991;49(14):PL91-6. doi: 10.1016/0024-3205(91)90307-w.
A single systemic administration of acromelic acid A (ACRO), a novel kainate analogue (kainoid), induces a series of characteristic behavioral changes in association with selective damage of interneurons in the caudal spinal cord in adult rats. When ACRO (5 mg/kg) was systemically administered, rats displayed forced extension of hindlimbs followed by frequent cramps and generalized convulsion. Most rats died during the convulsions without neuropathological change. Two rats developed long-lasting spastic paraparesis which persisted at least 3 months. Neuropathological changes were observed only in the rats with persistent paraparesis, in which neuron damage was identified selectively in small interneurons in the lumbosacral cord. The regional difference between kainate- and ACRO-induced neuron damage suggests the existence of plural kinds of kainate receptor subtypes.
单次全身给予新型红藻氨酸类似物（类红藻氨酸）——肢端酸A（ACRO），会在成年大鼠中引发一系列特征性行为变化，并伴有尾段脊髓中间神经元的选择性损伤。当全身给予ACRO（5毫克/千克）时，大鼠会出现后肢强迫伸展，随后频繁抽搐和全身性惊厥。大多数大鼠在惊厥过程中死亡，未出现神经病理学变化。两只大鼠出现了持续至少3个月的持久性痉挛性截瘫。仅在患有持续性截瘫的大鼠中观察到神经病理学变化，其中在腰骶脊髓的小中间神经元中选择性地发现了神经元损伤。红藻氨酸和ACRO诱导的神经元损伤之间的区域差异表明存在多种红藻氨酸受体亚型。
