Shinozaki H, Ishida M, Gotoh Y, Kwak S
Tokyo Metropolitan Institute of Medical Science, Japan.
Brain Res. 1989 Dec 4;503(2):330-3. doi: 10.1016/0006-8993(89)91685-5.
A single systemic injection of acromelic acid, a potent kainate analogue, caused behavioral and pathological effects distinct from those seen after systemic kainate. There was an initial marked tonic extension of the rat hindlimb, followed often by convulsions and, in surviving rats, by a transient flaccid paralysis and, ultimately, a persistent spastic paraplegia. Pathological examination suggested specific lesions of interneurons in the lower spinal cord with little or no damage to the hippocampal neurons preferentially affected by systemic kainate.
单次全身注射强效红藻氨酸类似物肢端酸，所产生的行为和病理效应与全身注射红藻氨酸后的效应不同。大鼠后肢最初会出现明显的强直性伸展，随后常常会发生惊厥，在存活的大鼠中，还会出现短暂的弛缓性麻痹，最终发展为持续性痉挛性截瘫。病理检查表明，脊髓下部的中间神经元有特异性损伤，而全身注射红藻氨酸时优先受影响的海马神经元几乎没有或没有损伤。
