Baĭsogolov G D, Shakhtarina S V, Afanasova N V
Med Radiol (Mosk). 1991;36(8):4-7.
The paper is concerned with analysis of the peculiarities of a course of disease and effectiveness of different therapeutic programs in 121 primary patients suffering from Hodgkin's disease with generalized lung lesion (true stage IV). The 5-year total and recurrence-free survival of patients after polychemoradiotherapy was 59.5 and 45.6%, respectively. Prognosis of disease in patient with generalized lung lesion is determined mainly by the development of a specific process in pulmonary tissue and, to a lesser degree, by spreading of disease via the lymphatic collectors. The authors have shown the appropriateness of combined therapy of this group of patients. Therapy includes cycles of polychemotherapy for achieving remission and radiotherapy including total irradiation of the affected lung for its consolidation.
本文关注121例患有霍奇金病且伴有广泛性肺部病变（真正的IV期）的初治患者的病程特点及不同治疗方案的疗效。接受多程放化疗后患者的5年总生存率和无复发生存率分别为59.5%和45.6%。伴有广泛性肺部病变患者的疾病预后主要取决于肺组织中特定病变的发展，其次取决于疾病通过淋巴管的扩散。作者证明了该组患者联合治疗的合理性。治疗包括用于实现缓解的多程化疗周期以及用于巩固治疗的放疗，包括对患侧肺进行全肺照射。
