环磷酸腺苷对乳腺肿瘤病毒产生的调节作用。
Cyclic AMP regulation of mammary tumor virus production.
作者信息
Yang J, Nandi S
出版信息
J Virol. 1977 Feb;21(2):815-9. doi: 10.1128/JVI.21.2.815-819.1977.
Abstract
Addition of dibutyryl cyclic AMP (cAMP) and agents (isoproterenol and epinephrine) that stimulate the activities of adenylate cyclase enhance the stimulation of mammary tumor virus (MTV) production two- to threefold by glucocorticoid in short-term primary cultures of mammary tumors. This cAMP potentiation seems to depend on the stimulated level of MTV production by glucocorticoid alone, which increases MTV production 5- to 10-fold over basal level but varies greatly in absolute terms. When the stimulated level by glucocorticoid alone is suboptimal, cAMP seems to restore the sensitivity of the cells to the stimulatory effect of glucocorticoid to its maximum.
摘要
在乳腺肿瘤的短期原代培养中，添加二丁酰环磷酸腺苷（cAMP）以及刺激腺苷酸环化酶活性的试剂（异丙肾上腺素和肾上腺素），可使糖皮质激素对乳腺肿瘤病毒（MTV）产生的刺激作用增强两到三倍。这种cAMP增强作用似乎取决于仅由糖皮质激素刺激产生的MTV水平，该水平使MTV产量比基础水平增加5至10倍，但绝对值差异很大。当仅由糖皮质激素产生的刺激水平未达最佳时，cAMP似乎可将细胞对糖皮质激素刺激作用的敏感性恢复到最大值。
相似文献
1
Cyclic AMP regulation of mammary tumor virus production.环磷酸腺苷对乳腺肿瘤病毒产生的调节作用。
J Virol. 1977 Feb;21(2):815-9. doi: 10.1128/JVI.21.2.815-819.1977.
2
Role of natural prostaglandins in the control of murine mammary tumor virus expression.天然前列腺素在控制小鼠乳腺肿瘤病毒表达中的作用。
J Cancer Res Clin Oncol. 1982;103(1):55-67. doi: 10.1007/BF00410306.
3
Relationship between organization of mammary tumors and the ability of tumor cells to replicate mammary tumor virus and to recognize growth-inhibitory contact signals in vitro.乳腺肿瘤的组织结构与肿瘤细胞在体外复制乳腺肿瘤病毒及识别生长抑制性接触信号能力之间的关系。
J Virol. 1972 Feb;9(2):367-76. doi: 10.1128/JVI.9.2.367-376.1972.
4
Relationship between receptor and mammary tumour virus production after stimulation by glucocorticoid.糖皮质激素刺激后受体与乳腺肿瘤病毒产生之间的关系。
Nature. 1976 Jul 8;262(5564):107-12. doi: 10.1038/262107a0.
5
Effect of adrenergic agents on alpha-amylase release and adenosine 3',5'-monophosphate accumulation in rat parotid tissue slices.肾上腺素能药物对大鼠腮腺组织切片中α-淀粉酶释放及3',5'-环磷酸腺苷积累的影响。
Biochim Biophys Acta. 1975 May 5;392(1):82-94. doi: 10.1016/0304-4165(75)90168-3.
6
7
Conditions for optimal MTV synthesis in vitro and the effect of steroid hormones on virus production.体外最佳MTV合成条件及类固醇激素对病毒产生的影响。
Virology. 1974 Nov;62(1):242-52. doi: 10.1016/0042-6822(74)90319-5.
8
Prostaglandin regulation of murine mammary tumor virus production: a basis for some of the glucocorticoid and prolactin actions on mammary tumor cell cultures.
Prostaglandins Leukot Med. 1982 Dec;9(6):641-55. doi: 10.1016/0262-1746(82)90021-x.
9
Enhanced production of mouse mammary tumor virus in dexamethasone-treated, 5-iododeoxyuridine-stimulated mammary tumor cell cultures.在地塞米松处理、5-碘脱氧尿苷刺激的乳腺肿瘤细胞培养物中，小鼠乳腺肿瘤病毒产量增加。
J Natl Cancer Inst. 1974 Jun;52(6):1881-6. doi: 10.1093/jnci/52.6.1881.
10
Replication of mouse mammary tumor virus in tissue culture. 1. Establishment of a mouse mammary tumor cell line, virus characterization, and quantitation of virus production.小鼠乳腺肿瘤病毒在组织培养中的复制。1. 小鼠乳腺肿瘤细胞系的建立、病毒特性鉴定及病毒产量的定量分析。
Virology. 1977 Mar;77(1):12-30. doi: 10.1016/0042-6822(77)90402-0.
引用本文的文献
1
Role of natural prostaglandins in the control of murine mammary tumor virus expression.天然前列腺素在控制小鼠乳腺肿瘤病毒表达中的作用。
J Cancer Res Clin Oncol. 1982;103(1):55-67. doi: 10.1007/BF00410306.
2
Effect of prostaglandins and cyclic adenosine 3',5'-monophosphate modulators on herpes simplex virus growth and interferon response in human cells.前列腺素和环磷酸腺苷调节剂对人细胞中单纯疱疹病毒生长及干扰素反应的影响
Infect Immun. 1980 Jan;27(1):158-67. doi: 10.1128/iai.27.1.158-167.1980.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Mechanisms of hormonal induction of enzymes.激素诱导酶的机制。
Metabolism. 1973 Jan;22(1):85-100. doi: 10.1016/0026-0495(73)90033-4.
3
Adenosine 3':5'-monophosphate and hormone interrelationships in the mammary gland of the rat during pregnancy and lactation.妊娠和哺乳期大鼠乳腺中3':5'-单磷酸腺苷与激素的相互关系。
Eur J Biochem. 1974 Sep 1;47(2):303-12. doi: 10.1111/j.1432-1033.1974.tb03694.x.
4
Role of cyclic nucleotides in cancer.环核苷酸在癌症中的作用。
Adv Cyclic Nucleotide Res. 1974;4(0):81-116.
5
Cyclic AMP and the transformation of fibroblasts.环磷酸腺苷与成纤维细胞的转化
Adv Cancer Res. 1974;19(0):303-29. doi: 10.1016/s0065-230x(08)60057-3.
6
Immunochemical characterization of two major polypeptides from murine mammary tumor virus.小鼠乳腺肿瘤病毒两种主要多肽的免疫化学特性分析
J Virol. 1974 Jun;13(6):1200-10. doi: 10.1128/JVI.13.6.1200-1210.1974.
7
Dibutyryl cyclic AMP: increase in viral particles associated with morphologic changes in leukemic cells.二丁酰环磷腺苷：与白血病细胞形态学改变相关的病毒颗粒增加。
Exp Mol Pathol. 1974 Apr;20(2):147-53. doi: 10.1016/0014-4800(74)90049-5.
8
Mechanism of action of glucocorticoids.糖皮质激素的作用机制。
Metabolism. 1974 Feb;23(2):159-202. doi: 10.1016/0026-0495(74)90113-9.
9
Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells.二丁酰环磷酸腺苷对杂交细胞中EB病毒诱导的影响。
J Virol. 1973 Dec;12(6):1442-5. doi: 10.1128/JVI.12.6.1442-1445.1973.
10
Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.高肿瘤发生率和低肿瘤发生率小鼠品系组织中小鼠乳腺肿瘤病毒基因的转录
J Mol Biol. 1973 Oct 5;79(4):663-79. doi: 10.1016/0022-2836(73)90070-3.
Zotero 插件