环磷酸腺苷对乳腺肿瘤病毒产生的调节作用。
Cyclic AMP regulation of mammary tumor virus production.
作者信息
Yang J, Nandi S
出版信息
J Virol. 1977 Feb;21(2):815-9. doi: 10.1128/JVI.21.2.815-819.1977.
Abstract
Addition of dibutyryl cyclic AMP (cAMP) and agents (isoproterenol and epinephrine) that stimulate the activities of adenylate cyclase enhance the stimulation of mammary tumor virus (MTV) production two- to threefold by glucocorticoid in short-term primary cultures of mammary tumors. This cAMP potentiation seems to depend on the stimulated level of MTV production by glucocorticoid alone, which increases MTV production 5- to 10-fold over basal level but varies greatly in absolute terms. When the stimulated level by glucocorticoid alone is suboptimal, cAMP seems to restore the sensitivity of the cells to the stimulatory effect of glucocorticoid to its maximum.
摘要
在乳腺肿瘤的短期原代培养中，添加二丁酰环磷酸腺苷（cAMP）以及刺激腺苷酸环化酶活性的试剂（异丙肾上腺素和肾上腺素），可使糖皮质激素对乳腺肿瘤病毒（MTV）产生的刺激作用增强两到三倍。这种cAMP增强作用似乎取决于仅由糖皮质激素刺激产生的MTV水平，该水平使MTV产量比基础水平增加5至10倍，但绝对值差异很大。当仅由糖皮质激素产生的刺激水平未达最佳时，cAMP似乎可将细胞对糖皮质激素刺激作用的敏感性恢复到最大值。
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