二丁酰环磷酸腺苷对杂交细胞中EB病毒诱导的影响。
Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells.
作者信息
Zimmerman J E, Glaser R, Rapp F
出版信息
J Virol. 1973 Dec;12(6):1442-5. doi: 10.1128/JVI.12.6.1442-1445.1973.
Abstract
Treatment of Epstein-Barr virus (EBV) negative somatic cell hybrids with 5'-iododeoxyuridine (IUdR) induced synthesis of EBV antigens and virus particles. When dibutyryl cAMP (Bt(2)-cAMP) was present in medium after exposure of cultures to IUdR, the incidence of cells synthesizing EBV early and virus capsid antigens was increased. The time necessary for appearance of EBV particles after induction by IUdR was significantly reduced in the presence of Bt(2)-cAMP. This enhancement was evident to a lesser degree with 3':5' cAMP than with Bt(2)-cAMP and did not occur with any other of the related compounds tested. The response observed was dose dependent. Untreated (no IUdR) EBV negative hybrid cells exposed to Bt(2)-cAMP also synthesized EBV antigens. The concentration of intracellular cAMP may act as one of the control mechanisms selecting for gene expression in this system.
摘要
用5'-碘脱氧尿苷（IUdR）处理爱泼斯坦-巴尔病毒（EBV）阴性体细胞杂种可诱导EBV抗原和病毒颗粒的合成。当培养物暴露于IUdR后，培养基中存在二丁酰环磷酸腺苷（Bt(2)-cAMP）时，合成EBV早期抗原和病毒衣壳抗原的细胞发生率增加。在Bt(2)-cAMP存在的情况下，IUdR诱导后EBV颗粒出现所需的时间显著缩短。与Bt(2)-cAMP相比，3':5'-环磷酸腺苷（cAMP）的这种增强作用程度较小，并且在所测试的任何其他相关化合物中均未出现。观察到的反应是剂量依赖性的。未处理（无IUdR）且暴露于Bt(2)-cAMP的EBV阴性杂种细胞也合成EBV抗原。细胞内cAMP的浓度可能作为该系统中选择基因表达的控制机制之一。
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