Persson R E, Izutsu K T, Treulove E L, Persson R
Department of Oral Medicine, Health Sciences Center, University of Washington, Seattle.
Oral Surg Oral Med Oral Pathol. 1991 Jul;72(1):42-6. doi: 10.1016/0030-4220(91)90187-h.
Stimulated whole salivary flow rate (SWSFR) was measured in a group of elderly subjects who were examined for the use of xerostomia-inducing medications. SWSFR was significantly reduced in elderly subjects using one of these medications when compared with control subjects (0.94 vs 1.52 ml/min). Increasing use of up to four different xerostomia-inducing medications did not result in additional significant reduction of stimulated salivary flow rate. Psychotropic and diuretic agents were the most commonly used xerostomatic medications, and these were almost equally potent in reducing mean flow rate (0.79 vs 0.84 ml/min). The use of potentially xerostomatic medications did not affect decayed, missing, or filled surface scores or unstimulated whole saliva pH values. A weak, statistically significant, positive correlation (r = 0.39, p less than 0.01) was found between subject age and salivary flow rate in this population of elderly subjects, and this suggests that SWSRF is influenced more by factors such as medication than by aging.
在一组接受口干燥症诱发药物使用检查的老年受试者中，测量了刺激后的全唾液流速（SWSFR）。与对照组受试者相比，使用这些药物之一的老年受试者的SWSFR显著降低（0.94对1.52毫升/分钟）。使用多达四种不同的口干燥症诱发药物，刺激唾液流速并未进一步显著降低。精神药物和利尿剂是最常用的致口干燥药物，它们在降低平均流速方面几乎同样有效（0.79对0.84毫升/分钟）。使用潜在的致口干燥药物并不影响龋失补牙面得分或非刺激全唾液pH值。在这群老年受试者中，受试者年龄与唾液流速之间存在微弱的、具有统计学意义的正相关（r = 0.39，p小于0.01），这表明SWSFR受药物等因素的影响大于衰老。
