Dental School, Faculty of Health Science, University of Brasília, Brasília-DF, Brazíl.
Gerodontology. 2010 Jun;27(2):129-33. doi: 10.1111/j.1741-2358.2009.00293.x. Epub 2010 Mar 11.
To compare stimulated and non-stimulated salivary flow, pH, buffering capacity and presence of signs and symptoms of hyposialie and xerostomia in elderly patients, with senile dementia using medication and healthy elderly subjects not using medication.
Forty individuals (mean age: 68.5 years) were divided into two groups, according to the use (G1) or non-use (G2) of medication and the presence (G1) or absence (G2) of senile dementia. Data with reference to the general health condition, use of medication and the patient's complaints were collected during anamnesis. Clinical examination identified signs associated with hyposialie and xerostomia. Stimulated and non-stimulated saliva flow, pH and buffering capacity were verified.
The stimulated saliva flow in both groups was below normal parameters. The drugs used by individuals in G1 showed xerostomic potential. Individuals with a higher consumption of xerostomic medication presented with dry and cracked lips. A significant negative relationship was found between drugs consumption and the buffering capacity (p < 0.001), and the resting saliva flow rate (p = 0.002).
The use of medication increases the chance that an elderly person may present signs related to xerostomia and alterations in stimulated saliva flow and buffering capacity.
比较使用药物治疗的老年痴呆症患者与未使用药物治疗的健康老年患者的刺激性和非刺激性唾液流量、pH 值、缓冲能力以及低分泌和口干症状的发生情况。
根据是否使用药物（G1 组和 G2 组）和是否患有老年痴呆症（G1 组和 G2 组），将 40 名（平均年龄：68.5 岁）个体分为两组。在病史采集过程中，收集与低分泌和口干相关的一般健康状况、用药情况和患者主诉的数据。临床检查确定与低分泌和口干相关的体征。检测刺激和非刺激唾液流量、pH 值和缓冲能力。
两组的刺激唾液流量均低于正常参数。G1 组个体使用的药物具有潜在的口干作用。口干药物消耗量较高的个体表现为嘴唇干燥和干裂。药物消耗与缓冲能力（p < 0.001）和静息唾液流量之间存在显著负相关（p = 0.002）。
药物的使用增加了老年人出现口干相关症状以及刺激唾液流量和缓冲能力改变的可能性。
