衰老对大鼠纹状体中环磷酸腺苷水平以及腺苷酸环化酶和磷酸二酯酶活性的影响。

Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum.

作者信息

Puri S K, Volicer L

出版信息

Mech Ageing Dev. 1977 Jan-Feb;6(1):53-8. doi: 10.1016/0047-6374(77)90006-9.

Abstract

Cyclic AMP levels and activities of adenylate cyclase and phosphodiesterase in the striatum were measured in 4, 12, 24 and 30 month-old rats. No age-related changes were observed either in cyclic AMP levels or basal adenylate cyclase activity. However, there was an age-related decline in dopamine sensitivity of adenylate cyclase without affecting NaF-induced stimulation. There was also an age-dependent decrease in phosphodiesterase activity at low substrate concentrations (3 X 10(-7) and 3 X 10(-6) M) but not at high substrate concentrations (3 X 10(-5) and 3 X 10(-4) M). These results suggest that the functions of dopaminergic neurons may have been altered by aging.

摘要

在4、12、24和30月龄的大鼠中测量了纹状体中环状AMP水平以及腺苷酸环化酶和磷酸二酯酶的活性。无论是环状AMP水平还是基础腺苷酸环化酶活性均未观察到与年龄相关的变化。然而，腺苷酸环化酶的多巴胺敏感性存在与年龄相关的下降，而不影响氟化钠诱导的刺激。在低底物浓度（3×10⁻⁷和3×10⁻⁶M）下磷酸二酯酶活性也存在年龄依赖性下降，但在高底物浓度（3×10⁻⁵和3×10⁻⁴M）下则没有。这些结果表明，多巴胺能神经元的功能可能已因衰老而改变。