衰老：紫贻贝（双壳纲）中多巴胺刺激的腺苷酸环化酶活性下降。
Aging: decline of dopamine-stimulated adenylate cyclase activity in Mytilus edulis (Bivalvia).
作者信息
Stefano G B, Stanec A, Catapane E J
出版信息
Cell Mol Neurobiol. 1982 Sep;2(3):249-53. doi: 10.1007/BF00711152.
Abstract
- Aging is a multivariate process which results from a progressive accumulation alterations including, for example, biochemical and physiological changes, in an organism with time. These alterations occur in short- and long-lived organisms, in invertebrates and vertebrates. 2. The present study demonstrates that the maximum responsiveness and sensitivity of dopamine-stimulated adenylate cyclase diminish with age as determined in pedal ganglion homogenates. The dopamine-blocking efficacy of chlorpromazine also decreased with age in 4-year-old organisms compared to 1- and 2-year-old organisms. However, adenylate cyclase activity does not diminish with age in response to the GTP stable analogue, Gpp(NH)p. 3. The results suggest that one aspect of aging in specifically affects dopamine interaction with this receptor-mediated system.
摘要
- 衰老 是一个多变量过程，它是由生物体随时间逐渐积累的变化导致的，这些变化包括例如生化和生理变化。这些变化发生在短寿命和长寿命的生物体中，包括无脊椎动物和脊椎动物。2. 本研究表明，如在足神经节匀浆中所测定的，多巴胺刺激的腺苷酸环化酶的最大反应性和敏感性随年龄增长而降低。与1岁和2岁的生物体相比，氯丙嗪对4岁生物体的多巴胺阻断效力也随年龄下降。然而，腺苷酸环化酶活性对GTP稳定类似物Gpp(NH)p的反应并不随年龄降低。3. 结果表明，衰老的一个方面特别影响多巴胺与这个受体介导系统的相互作用。
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